6ke2: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ke2 is ON HOLD  until Paper Publication
+==ABloop reengineered Ferritin Nanocage==
+<StructureSection load='6ke2' size='340' side='right'caption='[[6ke2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ke2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KE2 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ke2 OCA], [http://pdbe.org/6ke2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ke2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ke2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ke2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH &lt;/= 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage.
-Authors: Wang, W.M., Wang, H.F.
+AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.,Wang W, Wang L, Li G, Zhao G, Zhao X, Wang H Chem Commun (Camb). 2019 Oct 10;55(82):12344-12347. doi: 10.1039/c9cc05247j. PMID:31556881<ref>PMID:31556881</ref>
-Description: ABloop reengineered Ferritin Nanocage
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Wang, W.M]]
+<div class="pdbe-citations 6ke2" style="background-color:#fffaf0;"></div>
-[[Category: Wang, H.F]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ferroxidase]]
+[[Category: Large Structures]]
+[[Category: Wang, H F]]
+[[Category: Wang, W M]]
+[[Category: Abloop reengineered]]
+[[Category: Metal binding protein]]
+[[Category: Rhuhf]]