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| </StructureSection> | | </StructureSection> |
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| == 3D Structures of Lipase ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Eukaryote lipase:
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| **[[1hpl]] – hLip – horse <br />
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| **[[1hlg]] – hLip – human - gastric<br />
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| **[[1jmy]] – hBSSL <br />
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| **[[1akn]] – cBSSL – cattle <br />
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| **[[2bce]] - cBSSL (mutant) <br />
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| **[[1f6w]] - cBSSL – catalytic domain<br />
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| **[[3o0d]] – Lip – ''Yarrowia lipolytica''<br />
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| **[[4jei]] – YlLip (mutant)<br />
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| **[[1gpl]] – Lip – Guinea pig<br />
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| **[[3zpx]] – Lip – ''Ustilago maydis''<br />
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| **[[6a0w]] – Lip catalytic domain – bread mold<br />
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| **[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />
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| *Prokaryote lipase:
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| **[[1llf]] – Lip – ''Candida cylindracea''<br />
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| **[[3g7n]] – Lip - ''Penicillium expansum''<br />
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| **[[1tia]] - Lip – ''Penicillium camemberti''<br />
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| **[[2hih]] – Lip – ''Staphylococcus hyicus''<br />
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| **[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
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| **[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
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| **[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]] - TlLip - ''Thermomyces lanuginose''<br />
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| **[[5ap9]] – TlLip (mutant)<br />
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| **[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
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| **[[5mal]] – Lip – ''Streptomyces rimosus''<br />
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| **[[2lip]] – BcLip – open state<br />
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| **[[1cvl]] – Lip – ''Chromobacterium viscosum''<br />
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| **[[1tic]] - Lip – ''Rhizopus oryzae''<br />
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| **[[3tgl]], [[4tgl]], [[1tgl]], [[6qpp]] – RmLip – ''Rhyzomucor miehei''<br />
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| **[[6qpr]] – RmLip (mutant)<br />
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| **[[2zvd]] – PsLip - ''Pseudomonas sp.'' – open state<br />
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| **[[2z8x]] - PsLip – extracellular<br />
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| **[[5xpx]] – PsLip residues 1-388<br />
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| **[[2zj6]], [[2zj7]] – PsLip (mutant) <br />
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| **[[2z8z]] – PsLip(mutant) – closed state<br />
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| **[[3lip]], [[3a6z]] - Lip - ''Pseudomonas cepacia'' – open state<br />
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| **[[1qge]], [[1tah]] – Lip – ''Pseudomonas glumae''<br />
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| **[[2w22]], [[6a12]] – GtLip – ''Geobacillus thermocatenulatus''<br />
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| **[[5ce5]] – GtLip (mutant)<br />
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| **[[1ji3]], [[1ku0]], [[4fmp]], [[4x6u]] – BstLip – ''Bacillus stearothermophilus''<br />
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| **[[4x71]], [[4x7b]], [[4x85]], [[6s3g]], [[6s3j]], [[6s3v]], [[6fz1]], [[6fz7]], [[6fz8]], [[6fz9]], [[6fza]], [[6fzc]], [[6fzd]] – BstLip (mutant)<br />
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| **[[1ah7]] - Lip – ''Bacillus cereus''<br />
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| **[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
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| **[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
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| **[[3umj]] – GzLip (mutant)<br />
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| **[[3p94]] – Lip – ''Parabacteroides distasonis''<br />
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| **[[3ngm]] – Lip – ''Gibberella zeae''<br />
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| **[[3auk]] - Lip – ''Geobacillus''<br />
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| **[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
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| **[[4hs9]] – Lip – ''Proteus mirabilis''<br />
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| **[[4opm]] – Lip – ''Acinetobacter baumannii''<br />
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| **[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
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| **[[5ah1]] – Lip – ''Clostridium botulinum''<br />
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| **[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium''<br />
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| *Bacterial lipase A
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| **[[3guu]] – CaLipA – ''Candida Antarctica''<br />
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| **[[2veo]] – CaLipA – closed state<br />
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| **[[2qua]], [[2qub]] – SmLipA – ''Serratia marcescens''<br />
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| **[[2qxt]], [[2qxu]], [[1isp]], [[1i6w]], [[5ct4]], [[5ct5]], [[5ct6]], [[5cri]] - BsLipA – ''Bacillus subtilis''<br />
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| **[[3d2a]], [[3d2b]], [[3d2c]], [[1t2n]], [[1t4m]], [[5ct8]], [[5ct9]], [[5cta]], [[5cur]], [[3qzu]], [[3qmm]] - BsLipA (mutant) <br />
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| **[[1r4z]] – BsLipA+Rc-IPG-phosphonate<br />
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| **[[1r50]] – BsLipA +Sc-IPG-phosphonate<br />
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| *Bacterial lipase B
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| **[[4zv7]], [[3w9b]], [[5a6v]], [[5a71]], [[4k6g]], [[1tca]], [[1tcb]], [[1tcc]], [[1lbs]], [[1lbt]] – CaLipB <br />
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| **[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />
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| **[[5gv5]] - CaLipB + phosphonate<br />
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| **[[3icw]] – CaLipB (mutant) + phosphonate<br />
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| **[[5x7k]] – SmLipB NBD <br />
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| **[[6isp]], [[6isq]], [[6isr]] – LipB (mutant) – ''Pseudozyma antarctica''<br />
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| **[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />
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| *Bacterial lipase C
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| **[[5nen]] – SmLipC residues 1-443 <br />
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| *Lipase/colipase complexes. The colipase is a co-enzyme whose binding to lipase optimizes the enzymatic activity
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| **[[1n8s]] – hLip+colipase II<br />
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| **[[1eth]], [[1lpa]] - pLip+colipase II - pig<br />
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| *Hormone-sensitive-lipases (LIPE) hydrolyze the first fatty acid of the triacylglycerol substrate
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| **[[3k6k]] – EstE7(LIPE) – metagenome library<br />
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| **[[3fak]], [[3dnm]] – EstE5(LIPE) – metagenome library<br />
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| **[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
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| **[[1u4n]] – AaEst2(LIPE) (mutant) <br />
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| *Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.
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| **[[2rau]] - Lip – ''Sulfolobus solfataricus''<br />
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| **[[3bxp]], [[3d3n]] - Lip – ''Lactobacillus plantarum''<br />
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| **[[3e0x]] - Lip – ''Clostridium acetobutylicum''<br />
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| **[[1z8h]] – Lip – ''Nostoc sp.'' PCC 712<br />
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| **[[1vj3]] - Lip – ''Nostoc sp.'' <br />
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| **[[3bzw]] – Lip - ''Bacteroides thetaiotaomicron''<br />
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| **[[2pbl]] – Lip - ''Silicibacter''
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| *Lipase + inhibitors
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| **[[3l1h]] – EstE5(LIPE)+FeCl3 – noninvasive inhibitor<br />
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| **[[3l1i]], [[3l1j]] - EstE5(LIPE)+CuSO4 – noninvasive inhibitor<br />
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| **[[3lij]] - EstE5(LIPE)+ZnSO4– noninvasive inhibitor<br />
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| **[[3h18]], [[3h17]] - EstE5 (LIPE)+PMSF <br />
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| **[[3h19]], [[3h1b]], [[3h1a]] – EstE5 (LIPE)+methyl alcohol<br />
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| **[[3h1a]] – EstE5 SLIPE)+ethyl alcohol<br />
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| **[[3h19]] – EstE5 SLIPE)+isopropyl alcohol<br />
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| **[[3g9t]], [[3g9u]] - EstE5 (HSLIPE)+p-nitrophenyl butyrate<br />
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| **[[3g9z]] - EstE5 (LIPE) +p-nitrophenyl caprylate<br />
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| **[[2nw6]] – BcLip+ S inhibitor <br />
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| **[[4lip]], [[5lip]], [[1r4z]], [[1r50]] – BcLip+ Rc-(Rp,Sp)-1,2-dioctylcarbamoyl-glycero-3-O-phosphonate<br />
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| **[[1k8q]] - Lip+phosphonate – dog <br />
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| **[[1ex9]] – Lip+Rc-(Rp,Sp)-1,2-dioctylcarbamoyl-glycero-3-O-phosphonate – ''Pseudomonas aeruginosa'' <br />
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| **[[5tgl]] – RmLip+N-hexyl-phosphonate <br />
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| **[[1lpb]] – pLip + colipase+C11 alkyl phosphonate <br />
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| **[[3a70]] – PsLip+diethyl phosphate<br />
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| **[[4glb]] – TlLip + nitrobenzaldehyde<br />
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| **[[4kjx]] - TlLip + nitrobenzaldehyde + lauric acid<br />
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| **[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
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| **[[4s0x]] – TlLip + lauric acid<br />
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| *Lipase conjugated with analogs to its reaction intermediates
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| **[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />
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| *Bile-salt activated lipase
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| **[[6h0t]] – hBAL (mutant) <br />
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| **[[6h0v]], [[6h18]], [[6h19]], [[6h1a]] – hBAL (mutant) + nerve agent<br />
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| **[[1aql]] – bBAL+taurocholate - bovine<br />
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| *Monoacylglycerol lipase
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| **[[3hju]], [[3jw8]] - hMAGL <BR />
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| **[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]] – hMAGL + inhibitor<br />
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| **[[4uuq]] - hMAGLip + SAR <br />
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| **[[5zun]] – hMAGL (mutant) + inhibitor<br />
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| **[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' <BR />
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| **[[3rli]] – BaMAGL + PMSF<br />
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| **[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
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| **[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
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| **[[4zwn]] – yMAGL – yeast<br />
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| **[[4zxf]] – yMAGLip + substrate analog<br />
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| **[[6eic]] – MAGLip – ''Mycobacterium tuberculosis''<br />
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| **[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
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| *Lipase with substrate bound at active site
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| **[[2zyh]] – AfLip (mutant)+fatty acid – ''Archaeoglobus fulgidus''<br />
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| **[[2zyi]], [[2zyr]], [[2zys]] - AfLip+fatty acid+ ion <br />
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| **[[1gt6]], [[4ghw]], [[4gi1]] – TlLip+ fatty acid - lipid ligand<br />
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| *Lipase conjugated to transition-state analogs showing the binding mode of the enzyme catalysis
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| **[[1ys1]] – BhLip+hexylphosphonic acid (R) 2-methyl-3-phenylpropyl ester <br />
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| **[[1ys2]] – BhLip+hexylphosphonic acid (S) 2-methyl-3-phenylpropyl ester<br />
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| **[[1hqd]] – Lip+1-phenoxy-2-acrtoxy butane – ''Pseudomonas cepacia'' <br />
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| *Lipase+lipase chaperone
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| **[[2es4]] – Lip+lipase chaperone C-terminal - ''Burkholderia glumae''
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| *Lipase 2 or esterase/lipase
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| **[[3v9a]],[[3g9t]], [[3g9u]], [[3g9z]], [[3h19]], [[3h1a]], [[3h1b]], [[3l1h]], [[3l1i]], [[3l1j]], [[3fak]], [[3h17]], [[3h18]], [[3dnm]], [[3k6k]] - E/L - uncultured bacteria<br />
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| **[[3w9b]] - CaE/L <br />
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| **[[4v2i]] - E/L - ''Thalassospira''<br />
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| **[[4n5h]] - LrE/L (mutant) - ''Lactobacillus rhamnosus''<br />
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| **[[4n5i]] - LrE/L + inhibitor <br />
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| **[[4ouk]] - LrE/L (mutant) + inhibitor <br />
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| **[[4bzz]], [[4bzw]] - LpE/L <br />
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| **[[6gup]] - AfE/L <br />
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| **[[1lgy]] – Lip2 – ''Rhizopus niveus''<br />
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| **[[1gz7]] - CrLip2 <br />
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| **[[4jei]] – Lip2 – ''Yarrowia lipolytica''<br />
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| **[[1thg]] – Lip2 – ''Geotrichum candidum''<br />
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| }}
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| ==References== | | ==References== |
| <references /> | | <references /> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |