Lactate Dehydrogenase: Difference between revisions
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As the mechanism is one of equilibrium, There appears to be no regulation specifically designed for lactate dehydrogenase, instead it is dependent on the activation of anaerobic reparation and the presence of pyruvate and NADH, or lactate and NAD+. | As the mechanism is one of equilibrium, There appears to be no regulation specifically designed for lactate dehydrogenase, instead it is dependent on the activation of anaerobic reparation and the presence of pyruvate and NADH, or lactate and NAD+. | ||
==3D structures of lactate dehydrogenase== | |||
[[Lactate dehydrogenase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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*L-LDH | *L-LDH | ||
**[[4l4r]], [[4ojn]] – hLDH A chain – human<br /> | |||
**[[2ldx]] – C4-LDH - mouse<br /> | |||
**[[5k0z]] – LDH B chain – chicken<br /> | |||
**[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR /> | **[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR /> | ||
**[[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR /> | **[[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR /> | ||
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**[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR /> | **[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR /> | ||
**[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR /> | **[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR /> | ||
**[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br /> | **[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br /> | ||
**[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br /> | **[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br /> | ||
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**[[3vpg]] – TcLDH – ''Thermus caldophilus''<br /> | **[[3vpg]] – TcLDH – ''Thermus caldophilus''<br /> | ||
**[[3wsv]] – EmLDH – ''Enteroccocus mundtii''<br /> | **[[3wsv]] – EmLDH – ''Enteroccocus mundtii''<br /> | ||
**[[4uum]] – TvL-LDH – ''Trichomonas vaginalis''<br /> | **[[4uum]] – TvL-LDH – ''Trichomonas vaginalis''<br /> | ||
**[[4uul]] – TvL-LDH (mutant)<br /> | **[[4uul]] – TvL-LDH (mutant)<br /> | ||
**[[5hs4]] - PvL-LDH – ''Plasmodium vivax''<br /> | **[[5hs4]] - PvL-LDH – ''Plasmodium vivax''<br /> | ||
**[[ | **[[6or9]] – LDH – ''Trichoplusia''<br /> | ||
**[[6k12]] – BmLDH – ''Babesia microti''<br /> | |||
**[[6j9d]] – BmLDH (mutant)<br /> | |||
*L-LDH from yeast (cytochrome b2) | *L-LDH from yeast (cytochrome b2) | ||
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*''L-LDH binary complex'' | *''L-LDH binary complex'' | ||
**[[4ajp]], [[4m49]], [[4qsm]], [[4qt0]], [[5w8h]], [[5w8i]], [[5w8j]] – hLDH A chain + inhibitor <br /> | |||
**[[4l4s]] – hLDH α chain + NAD <br /> | |||
**[[5zje]] - hL-LDH A chain + malonate <br /> | |||
**[[5zjf]] - hL-LDH A chain + machilin<br /> | |||
**[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br /> | |||
**[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]], [[5kkc]] – raL-LDH A chain + inhibitor – rat<br /> | |||
**[[5es3]] – raL-LDH + oxamate<br /> | |||
**[[5nqb]] – raL-LDH A chain (mutant) + malonate<br /> | |||
**[[4b7u]] – PfL-LDH + bicine<BR /> | **[[4b7u]] – PfL-LDH + bicine<BR /> | ||
**[[1cet]] - PfL-LDH + chloroquine<BR /> | **[[1cet]] - PfL-LDH + chloroquine<BR /> | ||
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**[[6j9t]] - LcLDH + fructose-bisphosphate<br /> | **[[6j9t]] - LcLDH + fructose-bisphosphate<br /> | ||
**[[6j9u]] – LcLDH (mutant) + pyruvate<br /> | **[[6j9u]] – LcLDH (mutant) + pyruvate<br /> | ||
**[[4uun]] – TvL-LDH + NAD<br /> | **[[4uun]] – TvL-LDH + NAD<br /> | ||
**[[6h9s]] – LDH + NAD – ''Petrotoga mobilis''<br /> | |||
*''L-LDH ternary complex with inhibitor'' | *''L-LDH ternary complex with inhibitor'' | ||
**[[1t2f]] - hL-LDH B chain + azole derivative + NAD <BR /> | |||
**[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR /> | |||
**[[1i10]] - hL-LDH M chain + oxamate + NAD<BR /> | |||
**[[4qo7]], [[4qo8]], [[4r68]], [[4r69]], [[4rls]], [[4zvv]], [[5ixs]], [[5ixy]], [[5w8k]], [[5w8l]], [[6bad]], [[6bag]], [[6bax]], [[6baz]], [[6bb0]], [[6bb1]], [[6bb2]], [[6bb3]] - hL-LDH A chain + inhibitor + NAD<br /> | |||
**[[5zjd]] - hL-LDH A chain + malonate + NAD<br /> | |||
**[[9ldb]], [[9ldt]], [[6cep]], [[5yta]] - pL-LDH + oxamate + NAD – pig<br /> | |||
**[[3h3f]] – rL-LDH A chain + oxamate + NAD <BR /> | |||
**[[5nqq]] - rL-LDH A chain + oxalacetate + NAD<br /> | |||
**[[1u5c]] - PfL-LDH + inhibitor + NAD<BR /> | **[[1u5c]] - PfL-LDH + inhibitor + NAD<BR /> | ||
**[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR /> | **[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR /> | ||
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**[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br /> | **[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br /> | ||
**[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br /> | **[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br /> | ||
**[[4nd1]] - CpLDH + oxamate + NAD<BR /> | **[[4nd1]] - CpLDH + oxamate + NAD<BR /> | ||
**[[3wsw]] – EmL-LDH + NAD + fructose diphosphate<br /> | **[[3wsw]] – EmL-LDH + NAD + fructose diphosphate<br /> | ||
**[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR /> | **[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR /> | ||
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**[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR /> | **[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR /> | ||
**[[1ldn]] - GsL-LDH + oxamate + NAD<BR /> | **[[1ldn]] - GsL-LDH + oxamate + NAD<BR /> | ||
**[[4plc]], [[4plf]] – ApLDH + NAD + pyruvate - ''Apicomplexa''<br /> | **[[4plc]], [[4plf]] – ApLDH + NAD + pyruvate - ''Apicomplexa''<br /> | ||
**[[4plg]] – ApLDH + NAD + oxamate <br /> | **[[4plg]] – ApLDH + NAD + oxamate <br /> | ||
**[[5a1t]] – TvL-LDH + NAD + oxamate<br /> | **[[5a1t]] – TvL-LDH + NAD + oxamate<br /> | ||
**[[6k13]] – BmLDH + NAD + oxamate <br /> | |||
**[[6ct6]] – LDH + NAD + oxamate – ''Eimeria maxima''<br /> | |||
*''L-LDH ternary complex with reactants'' | *''L-LDH ternary complex with reactants'' | ||
**[[5ldh]] - pLDH + citrate + NAD-analog<br /> | |||
**[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR /> | **[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR /> | ||
**[[3d4p]] - SaL-LDH + pyruvate + NAD<BR /> | **[[3d4p]] - SaL-LDH + pyruvate + NAD<BR /> | ||
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**[[4nd2]] - CpLDH + pyruvate + NAD-analog<br /> | **[[4nd2]] - CpLDH + pyruvate + NAD-analog<br /> | ||
**[[4nd4]] - CpLDH + pyruvate + NAD<BR /> | **[[4nd4]] - CpLDH + pyruvate + NAD<BR /> | ||
**[[3ldh]] - sdLDH + pyruvate + NAD<BR /> | **[[3ldh]] - sdLDH + pyruvate + NAD<BR /> | ||
**[[3pqd]] - BsLDH + fructose-bisphosphate + NAD | **[[3pqd]] - BsLDH + fructose-bisphosphate + NAD | ||
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**[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR /> | **[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR /> | ||
**[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''<br /> | **[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''<br /> | ||
**[[3wwy]] – | **[[3wwy]], [[6abi]] – FnD-LDH – ''Fusobacterium nucleatum''<br /> | ||
**[[3wwz]] – | **[[5z21]] – FnD-LDH + NAD + oxamate<br /> | ||
**[[3wwz]] – PaD-LDH – ''Peudomonas aeruginosa''<br /> | |||
**[[5z20]] – FnD-LDH + NAD + oxamate<br /> | |||
**[[4xkj]] – D-LDH + NAD – ''Sporolactobacillus inulinus''<br /> | **[[4xkj]] – D-LDH + NAD – ''Sporolactobacillus inulinus''<br /> | ||
**[[4cuj]] – SeD-LDH – ''Salmonella enterica''<br /> | **[[4cuj]] – SeD-LDH – ''Salmonella enterica''<br /> | ||
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*1- http://www.jbc.org/content/243/17/4526.full.pdf+html | *1- http://www.jbc.org/content/243/17/4526.full.pdf+html | ||
[[Category:Topic | [[Category:Topic PagePa | ||