1cxv: Difference between revisions
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==STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)== | ==STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)== | ||
<StructureSection load='1cxv' size='340' side='right' caption='[[1cxv]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1cxv' size='340' side='right'caption='[[1cxv]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1cxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CXV FirstGlance]. <br> | <table><tr><td colspan='2'>[[1cxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CXV FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1cxv" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1cxv" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Matrix metalloproteinase|Matrix metalloproteinase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Botos, I]] | [[Category: Botos, I]] | ||
Revision as of 10:19, 10 October 2019
STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)
Structural highlights
Function[MMP13_MOUSE] Degrades collagen type I. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe matrix metalloproteinases are crucial in the physiological and pathological degradation of the mammalian extracellular matrix, including breast tumours, and osteoarthritic cartilage. These enzymes are classified according to their matrix substrate specificity. Collagenase-3 (MMP-13) is a member of this family and preferentially cleaves type II collagen, cartilage, fibronectin and aggrecan. Collagenase-3 is normally expressed in hypertrophic chondrocytes, periosteal cells, and osteoblasts during bone development. The structure of the catalytic domain of recombinant mouse collagenase-3, complexed to the hydroxamate inhibitor (RS-113456), is reported at 2.0 A resolution. Molecular replacement and weak phasing information from a single derivative determined the structure. Neither molecular replacement nor derivative methods had a sufficient radius of convergence to yield a refinable structure. The structure illuminates the atomic zinc ion interactions with functional groups in the active site, emphasizing zinc ligation and the very voluminous hydrophobic P1' group for the inhibitor potency. The structure provides insight into the specificity of this enzyme, facilitating design of specific inhibitors to target various diseases. Structure of recombinant mouse collagenase-3 (MMP-13).,Botos I, Meyer E, Swanson SM, Lemaitre V, Eeckhout Y, Meyer EF J Mol Biol. 1999 Oct 1;292(4):837-44. PMID:10525409[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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