6ugd: Difference between revisions

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'''Unreleased structure'''


The entry 6ugd is ON HOLD
==Katanin hexamer in the spiral conformation in complex with substrate==
 
<StructureSection load='6ugd' size='340' side='right'caption='[[6ugd]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ugd]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UGD FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Microtubule-severing_ATPase Microtubule-severing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.6.1.1 5.6.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ugd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ugd OCA], [http://pdbe.org/6ugd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ugd RCSB], [http://www.ebi.ac.uk/pdbsum/6ugd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ugd ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KTNA1_CAEEL KTNA1_CAEEL]] Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles (PubMed:8027178, PubMed:10809666, PubMed:12885567). In body wall muscles, regulates organization of myosin thick filaments (PubMed:22621901).[HAMAP-Rule:MF_03023]<ref>PMID:10809666</ref> <ref>PMID:12885567</ref> <ref>PMID:22621901</ref> <ref>PMID:8027178</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Microtubule-severing ATPase]]
[[Category: Roll-Mecak, A]]
[[Category: Zehr, E A]]
[[Category: Katanin]]
[[Category: Mei-1]]
[[Category: Microtubule cytoskeleton]]
[[Category: Microtubule-severing]]
[[Category: Motor protein]]

Revision as of 08:29, 10 October 2019

Katanin hexamer in the spiral conformation in complex with substrateKatanin hexamer in the spiral conformation in complex with substrate

Structural highlights

6ugd is a 7 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Microtubule-severing ATPase, with EC number 5.6.1.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KTNA1_CAEEL] Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles (PubMed:8027178, PubMed:10809666, PubMed:12885567). In body wall muscles, regulates organization of myosin thick filaments (PubMed:22621901).[HAMAP-Rule:MF_03023][1] [2] [3] [4]

References

  1. ↑ Srayko M, Buster DW, Bazirgan OA, McNally FJ, Mains PE. MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis. Genes Dev. 2000 May 1;14(9):1072-84. PMID:10809666
  2. ↑ Yang HY, McNally K, McNally FJ. MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans. Dev Biol. 2003 Aug 1;260(1):245-59. PMID:12885567
  3. ↑ Wilson KJ, Qadota H, Mains PE, Benian GM. UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans. Mol Biol Cell. 2012 Jul;23(14):2623-34. doi: 10.1091/mbc.E12-01-0055. Epub 2012, May 23. PMID:22621901 doi:http://dx.doi.org/10.1091/mbc.E12-01-0055
  4. ↑ Clark-Maguire S, Mains PE. Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component. J Cell Biol. 1994 Jul;126(1):199-209. PMID:8027178

6ugd, resolution 3.50Å

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