6igv: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 6igv is ON HOLD  until Paper Publication
==Kif5b stalk I coiled-coil==
 
<StructureSection load='6igv' size='340' side='right'caption='[[6igv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Zhang, S.J., Sun, W.p., Kong, B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6igv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IGV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IGV FirstGlance]. <br>
Description: Kif5b stalk I coiled-coil
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6igv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6igv OCA], [http://pdbe.org/6igv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6igv RCSB], [http://www.ebi.ac.uk/pdbsum/6igv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6igv ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Zhang, S.J]]
== Function ==
[[http://www.uniprot.org/uniprot/KINH_MOUSE KINH_MOUSE]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).[UniProtKB:P33176][UniProtKB:Q2PQA9]<ref>PMID:21976701</ref> <ref>PMID:9657148</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Kong, B]]
[[Category: Kong, B]]
[[Category: Sun, W.P]]
[[Category: Sun, W p]]
[[Category: Zhang, S J]]
[[Category: Coiled-coil]]
[[Category: Motor protein]]

Revision as of 08:16, 10 October 2019

Kif5b stalk I coiled-coilKif5b stalk I coiled-coil

Structural highlights

6igv is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KINH_MOUSE] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).[UniProtKB:P33176][UniProtKB:Q2PQA9][1] [2]

References

  1. ↑ Matsuzaki F, Shirane M, Matsumoto M, Nakayama KI. Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Mol Biol Cell. 2011 Dec;22(23):4602-20. doi: 10.1091/mbc.E11-01-0068. Epub 2011, Oct 5. PMID:21976701 doi:http://dx.doi.org/10.1091/mbc.E11-01-0068
  2. ↑ Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, Hirokawa N. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Cell. 1998 Jun 26;93(7):1147-58. PMID:9657148

6igv, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=6igv&oldid=3094083"