Synaptotagmin: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
SYT-2 structure contains the SMP (synaptotagmin-like-mitochondrial-lipid binding) domain, followed by the <scene name='80/802718/Cv/ | SYT-2 structure contains the SMP (synaptotagmin-like-mitochondrial-lipid binding) domain, followed by the <scene name='80/802718/Cv/7'>C2A Ca+2-binding, C2B</scene>, spacer and C2C domains. At the cup-shaped cavity at the of SYT C2A domain there are three tightly clustered Ca+2 binding sites formed by canonical 5 aspartates<ref>PMID:24373768</ref>. | ||
*<scene name='80/802718/Cv/ | *<scene name='80/802718/Cv/8'>1st Ca+2 binding site</scene>. Water molecules are shown as red spheres. | ||
*<scene name='80/802718/Cv/ | *<scene name='80/802718/Cv/9'>2nd Ca+2 binding site</scene>. | ||
*<scene name='80/802718/Cv/ | *<scene name='80/802718/Cv/10'>3th Ca+2 binding site</scene>. | ||
*<scene name='80/802718/Cv/ | *<scene name='80/802718/Cv/11'>All Ca+2 binding sites</scene>. | ||
</StructureSection> | </StructureSection> |