Survivin: Difference between revisions

Revision as of 14:32, 16 September 2019

Function

Survivin or apoptosis inhibitor 4 (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation^[1]. Survivin is part of the chromosomal passanger complex (CPC) which includes also Borealin and INCENP ^[2].

Disease

IAP4 is found in human cancer cells^[3]. and can serve as a cancer marker and as a target for chemotherapy^[4].

(PDB code 3uig).
(PDB code 3uig).

Structure of human survivin dimer (magenta and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code 3uig).

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3D structures of survivin3D structures of survivin

Updated on 16-September-2019

ReferencesReferences

↑ Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. PMID:9850056
↑ Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. PMID:23175282 doi:http://dx.doi.org/10.1038/nrm3474
↑ Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M, Erdas R, Cabras A, Kusamura S, Baratti D, Deraco M, Daidone MG. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol. 2007;29(6):453-66. PMID:18032822
↑ Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, Hehlgans S. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19(22):3679-88. PMID:22680927

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. PMID:9850056

[2] Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. PMID:23175282 doi:http://dx.doi.org/10.1038/nrm3474

[3] Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M, Erdas R, Cabras A, Kusamura S, Baratti D, Deraco M, Daidone MG. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol. 2007;29(6):453-66. PMID:18032822

[4] Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, Hehlgans S. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19(22):3679-88. PMID:22680927

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@@ Line 8: / Line 8: @@
 IAP4 is found in human cancer cells<ref>PMID:18032822</ref>. and can serve as a cancer marker and as a target for chemotherapy<ref>PMID:22680927</ref>.
-*<scene name='59/596423/Cv/4'>Human survivin interactions with histone H3 peptide</scene> (PDB code [[3uig]]).
+*<scene name='59/596423/Cv/6'>Human survivin interactions with histone H3 peptide</scene> (PDB code [[3uig]]).
-*<scene name='59/596423/Cv/5'>Zn coordination site in the human survivin</scene> (PDB code [[3uig]]).
+*<scene name='59/596423/Cv/7'>Zn coordination site in the human survivin</scene> (PDB code [[3uig]]).
 </StructureSection>