Interleukin: Difference between revisions

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== Disease ==
== Disease ==
IL deficiency results in autoimmune disease<ref>PMID:19494218</ref>.
IL deficiency results in autoimmune disease<ref>PMID:19494218</ref>.
==3D structures of interleukin==
[[Interleukin 3D structures]]


</StructureSection>
</StructureSection>
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**[[3qb1]] - hIL-2 (mutant)<br />
**[[3qb1]] - hIL-2 (mutant)<br />
**[[1irl]] – hIL-2 (mutant) - NMR<BR />
**[[1irl]] – hIL-2 (mutant) - NMR<BR />
**[[4zf7]] – hIL-2 - ferret<BR />
**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />
**[[2erj]], [[2b5i]] - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ<BR />
**[[2erj]], [[2b5i]] - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ<BR />
**[[1z92]] - hIL-2 + IL-2 receptor α<BR />
**[[1z92]] - hIL-2 + IL-2 receptor α<BR />
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**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
**[[5lqb]] - hIL-2 + antibody<br />
**[[4yue]] - mIL-2 + antibody<br />
**[[4yue]] - mIL-2 + antibody<br />
**[[4yqx]] - IL-2 + antibody - rat<br />
**[[4yqx]] - IL-2 + antibody - rat<br />
**[[4zf7]] – hIL-2 - ferret<BR />


*IL-3
*IL-3


**[[1jli]] – hIL-3 (mutant) – NMR<BR />
**[[1jli]] – hIL-3 (mutant) – NMR<BR />
**[[5uv8]], [[5uwc]] – hIL-3 (mutant) + IL-3 receptor α<BR />
**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR
**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR


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**[[2cyk]], [[1cyl]], [[1itm]], [[1bbn]], [[1bcn]], [[1iti]], [[1itl]] – hIL-4 - NMR<BR />
**[[2cyk]], [[1cyl]], [[1itm]], [[1bbn]], [[1bcn]], [[1iti]], [[1itl]] – hIL-4 - NMR<BR />
**[[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[1hzi]], [[1hij]] - hIL-4 (mutant) <BR />
**[[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[1hzi]], [[1hij]] - hIL-4 (mutant) <BR />
**[[5fhx]] - hIL-4 + antibody<BR />
**[[1iar]] - hIL-4 + IL-4 receptor α (mutant) <BR />
**[[1iar]] - hIL-4 + IL-4 receptor α (mutant) <BR />
**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
**[[6oel]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ + antibody<BR />
**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
**[[4ydy]] – hIL-4 + darpin<BR />
**[[4ydy]] – hIL-4 + darpin<BR />
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**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6<br />
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
**[[4cni]], [[4o9h]] – hIL-6 + antibody<BR />
**[[4cni]], [[4o9h]], [[4zs7]] – hIL-6 + antibody<BR />
**[[2l3y]] - mIL-6 residues 27-211 - NMR<br />
**[[2l3y]] - mIL-6 residues 27-211 - NMR<br />
**[[1i16]] – IL-6 + IL-6 receptor β - Herpesvirus 8<br />
**[[1i16]] – IL-6 + IL-6 receptor β - Herpesvirus 8<br />
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**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
**[[1il8]], [[2il8]] – hIL-8 - NMR<BR />
**[[1il8]], [[2il8]], [[5wdz]] – hIL-8 - NMR<BR />
**[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
**[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
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**[[1f42]] - hIL-12 β P40 domain<BR />
**[[1f42]] - hIL-12 β P40 domain<BR />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
**[[4oe8]], [[4og9]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />
**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />
**[[5mxa]] - hIL-12 β + hIL- 23 α<br />
**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
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**[[3l5w]], [[3l5x]], [[3g6d]], [[4i77]], [[4ps4]] - hIL-13 residues 35-146 + antibody<BR />
**[[3l5w]], [[3l5x]], [[3g6d]], [[4i77]], [[4ps4]] - hIL-13 residues 35-146 + antibody<BR />
**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α
**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α<br />
**[[5l6y]] - hIL-13 + antibody<br />


*IL-15
*IL-15
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**[[4hr9]] - hIL-17A (mutant)<br />
**[[4hr9]] - hIL-17A (mutant)<br />
**[[5n92]] - hIL-17A + hIL-17F <br />
**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
**[[2vxs]] - hIL-17A residues 20-255 + antibody<BR />
**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />
**[[2vxs]], [[4qhu]] - hIL-17A + antibody<BR />
**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
**[[1jpy]] – hIL-17F<BR />
**[[1jpy]] – hIL-17F<BR />
**[[3jvf]] - hIL-17F + IL-17 receptor α
**[[3jvf]] - hIL-17F + IL-17 receptor α
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**[[4grw]] - hIL-23 α + + hIL-12 β + nanobody<BR />
**[[4grw]] - hIL-23 α + + hIL-12 β + nanobody<BR />
**[[3duh]] - hIL-23 α + hIL-12 β
**[[3duh]] - hIL-23 α + hIL-12 β
*IL-24
**[[6gg1]] - hIL-24<br />
**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β<br />


*IL-28
*IL-28


**[[3hhc]] – hIL-28B
**[[3hhc]] – hIL-28B<br />
**[[5t5w]] - hIL-28B + IL—10 receptor β + IL-28 receptor α<br />


*IL-29
*IL-29
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**[[4ize]] - hIL-36 γ<br />
**[[4ize]] - hIL-36 γ<br />
**[[6p9e]] - hIL-36 g + antagonist<br />
*IL-37


**[[6ncu]], [[5hn1]] - hIL-37<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 12:03, 3 September 2019


Function

Interleukin (IL) is a cytokine which functions in the immune system. IL families are denoted by numbers[1].

  • IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See Interleukin-1 beta.
  • IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.
  • IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.
  • IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-5 stimulates B cell growth and increases immunoglobulin secretion.
  • IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.
  • IL-7 is a cytokine important for B and T cells development.
  • IL-8 induces chemotaxis and phagocytosis.
  • IL-10 see Interleukin-10 and Inflammation & Rheumatoid Arthritis.
  • IL-11 involved in the stimulation of megakaryocyte maturation.
  • IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.
  • IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-15 see Interleukin-15.
  • IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.
  • IL-17 recruits monocytes and neutrophils to the site of inflammation.
  • IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.
  • IL-19 induces activation of the signal transducer and activator of STAT3.
  • IL-21 has potent effect on natural killer cells.
  • IL-22 stimulates inflammatory responses like S100 and defensin.
  • IL-23 induces activation of the signal transducer and activator of STAT4.
  • IL-28 has a role in the immune defense against viruses.
  • IL-29 similar to IL-28.
  • IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.
  • IL-34 increases growth or survival of monocytes.
  • IL-36 acts on naïve CD4+ T cells.

Relevance

Uncontrolled activation of IL-1 is a component of of some inflammatory diseases including gout[2].

IL-8 is implicated in inflammatory lung diseases[3].
IL-10 is implicated in inflammatory bowel disease[4].
IL-10 is a potent anti-inflammatory agent[5].
IL-23 is implicated in Crohn's disease[6].

Disease

IL deficiency results in autoimmune disease[7].

3D structures of interleukin

Interleukin 3D structures


Human interleukin-1 β chain complex with sulfate, 2nvh

Drag the structure with the mouse to rotate

3D structures of interleukin3D structures of interleukin

Updated on 03-September-2019

ReferencesReferences

  1. ↑ Dinarello CA. Biology of interleukin 1. FASEB J. 1988 Feb;2(2):108-15. PMID:3277884
  2. ↑ Schett G, Dayer JM, Manger B. Interleukin-1 function and role in rheumatic disease. Nat Rev Rheumatol. 2016 Jan;12(1):14-24. doi: 10.1038/nrrheum.2016.166. Epub 2015, Dec 10. PMID:26656658 doi:http://dx.doi.org/10.1038/nrrheum.2016.166
  3. ↑ Pease JE, Sabroe I. The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med. 2002;1(1):19-25. PMID:14720072
  4. ↑ Shah N, Kammermeier J, Elawad M, Glocker EO. Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease. Curr Allergy Asthma Rep. 2012 Oct;12(5):373-9. doi: 10.1007/s11882-012-0286-z. PMID:22890722 doi:http://dx.doi.org/10.1007/s11882-012-0286-z
  5. ↑ Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32(1):23-63. PMID:22428854
  6. ↑ Eken A, Singh AK, Oukka M. Interleukin 23 in Crohn's disease. Inflamm Bowel Dis. 2014 Mar;20(3):587-95. doi:, 10.1097/01.MIB.0000442014.52661.20. PMID:24481050 doi:http://dx.doi.org/10.1097/01.MIB.0000442014.52661.20
  7. ↑ Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgard U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med. 2009 Jun 4;360(23):2426-37. doi: 10.1056/NEJMoa0807865. PMID:19494218 doi:10.1056/NEJMoa0807865

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Michal Harel, Joel L. Sussman, Alexander Berchansky
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