Pseudouridine: Difference between revisions
avoid confusion between bases, nucleosides and nucleotides |
m add transfer RNA |
||
| Line 7: | Line 7: | ||
In contrast to the formation of several other types of modifications where moieties are added covalently to the bases or backbone, the formation of pseudouridine from uridine is mechanistically rather complex. In order to form this modified nucleotide, the base has to be removed from the uridine monophospate, rotated, and covalently rebonded to form pseudouridine. | In contrast to the formation of several other types of modifications where moieties are added covalently to the bases or backbone, the formation of pseudouridine from uridine is mechanistically rather complex. In order to form this modified nucleotide, the base has to be removed from the uridine monophospate, rotated, and covalently rebonded to form pseudouridine. | ||
Most [[TRNA|tRNAs]] contain modified nucleotides<ref>PMID:20459084</ref>, which are generated post-transcriptionally by specific enzymes. Archaeal and eukaryotic rRNAs are well known to be targets of guided pseudouridine formation by protein-small RNA complexes. However, recent studies have revealed many more pseudouridines exist in messenger RNA in humans than appreciated before<ref>PMID: 25192136</ref><ref>PMID: 25367125</ref><ref>PMID: 30414851</ref>. | Most [[TRNA|transfer RNAs(tRNAs)]] contain modified nucleotides<ref>PMID:20459084</ref>, which are generated post-transcriptionally by specific enzymes. Archaeal and eukaryotic rRNAs are well known to be targets of guided pseudouridine formation by protein-small RNA complexes. However, recent studies have revealed many more pseudouridines exist in messenger RNA in humans than appreciated before<ref>PMID: 25192136</ref><ref>PMID: 25367125</ref><ref>PMID: 30414851</ref>. | ||
== Representation == | == Representation == | ||
| Line 56: | Line 56: | ||
==See also== | ==See also== | ||
*[[Transfer RNA (tRNA)]] | |||
* [[Ribosome]] | * [[Ribosome]] | ||