6hdu: Difference between revisions

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-'''Unreleased structure'''
-The entry 6hdu is ON HOLD  until Paper Publication
+==Crystal structure of human Rab38 in complex with GTP==
+<StructureSection load='6hdu' size='340' side='right'caption='[[6hdu]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hdu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HDU FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hdu OCA], [http://pdbe.org/6hdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hdu RCSB], [http://www.ebi.ac.uk/pdbsum/6hdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hdu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RAB38_HUMAN RAB38_HUMAN]] May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).[UniProtKB:Q8QZZ8]<ref>PMID:21255211</ref> <ref>PMID:23084991</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Khan, A R]]
+[[Category: McGrath, E]]
+[[Category: Waschbusch, D]]
+[[Category: Cellular dynamic]]
+[[Category: Membrane trafficking]]
+[[Category: Rab small gtpase]]
+[[Category: Signaling protein]]