5qs8: Difference between revisions
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==PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z1432018343== | |||
<StructureSection load='5qs8' size='340' side='right'caption='[[5qs8]], [[Resolution|resolution]] 1.47Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qs8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QS8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O0G:(2S)-2-[(5-chloro-3-fluoropyridin-2-yl)amino]propan-1-ol'>O0G</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qs8 OCA], [http://pdbe.org/5qs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qs8 RCSB], [http://www.ebi.ac.uk/pdbsum/5qs8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qs8 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Burgess-Brown, N A]] | |||
[[Category: Delft, F von]] | |||
[[Category: Edwards, A]] | |||
[[Category: Gavard, A E]] | |||
[[Category: Gileadi, O]] | |||
[[Category: Newman, J A]] | |||
[[Category: Sherestha, L]] | [[Category: Sherestha, L]] | ||
[[Category: | [[Category: Pandda]] | ||
[[Category: | [[Category: Sgc - diamond i04-1 fragment screening]] | ||
[[Category: Transcription]] | |||
[[Category: Xchemexplorer]] | |||
[[Category: | |||
[[Category: | |||
Revision as of 08:45, 21 August 2019
PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z1432018343PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z1432018343
Structural highlights
Disease[TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry. Function[TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293] |
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