2jha: Difference between revisions

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THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE

OverviewOverview

Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series, of four chemical reactions. Some viruses achieve this using a single, molecule; the crystal structure of such an enzyme from bluetongue virus, reveals an elongated modular architecture that provides a scaffold for an, assemblage of active sites, two contributed by a domain of novel, structure.

About this StructureAbout this Structure

2JHA is a Single protein structure of sequence from Bluetongue virus 10 (isolate usa) with GP3 and GUN as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.

ReferenceReference

Bluetongue virus VP4 is an RNA-capping assembly line., Sutton G, Grimes JM, Stuart DI, Roy P, Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654

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