6edw: Difference between revisions

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'''Unreleased structure'''


The entry 6edw is ON HOLD until Paper Publication
==Crystal structure of Mycobacterium tuberculosis ICL2 in the apo form==
 
<StructureSection load='6edw' size='340' side='right'caption='[[6edw]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6edw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EDW FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6edz|6edz]], [[6ee1|6ee1]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_lyase Isocitrate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.1 4.1.3.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6edw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6edw OCA], [http://pdbe.org/6edw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6edw RCSB], [http://www.ebi.ac.uk/pdbsum/6edw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6edw ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ACEA2_MYCTO ACEA2_MYCTO]] Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.<ref>PMID:10572116</ref> <ref>PMID:15895072</ref> <ref>PMID:16879647</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Isocitrate lyase]]
[[Category: Large Structures]]
[[Category: Bashiri, G]]
[[Category: Bhusal, R]]
[[Category: Leung, I]]
[[Category: Lyase]]

Revision as of 19:26, 14 August 2019

Crystal structure of Mycobacterium tuberculosis ICL2 in the apo formCrystal structure of Mycobacterium tuberculosis ICL2 in the apo form

Structural highlights

6edw is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Activity:Isocitrate lyase, with EC number 4.1.3.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ACEA2_MYCTO] Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.[1] [2] [3]

References

  1. ↑ Honer Zu Bentrup K, Miczak A, Swenson DL, Russell DG. Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis. J Bacteriol. 1999 Dec;181(23):7161-7. PMID:10572116
  2. ↑ Munoz-Elias EJ, McKinney JD. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat Med. 2005 Jun;11(6):638-44. doi: 10.1038/nm1252. Epub 2005 May 15. PMID:15895072 doi:http://dx.doi.org/10.1038/nm1252
  3. ↑ Gould TA, van de Langemheen H, Munoz-Elias EJ, McKinney JD, Sacchettini JC. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7. doi: 10.1111/j.1365-2958.2006.05297.x. PMID:16879647 doi:http://dx.doi.org/10.1111/j.1365-2958.2006.05297.x

6edw, resolution 1.80Å

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