6k5r: Difference between revisions
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==Complex of SUMO2 with Phosphorylated viral SIM IE2== | |||
<StructureSection load='6k5r' size='340' side='right'caption='[[6k5r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6k5r]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K5R FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k5r OCA], [http://pdbe.org/6k5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k5r RCSB], [http://www.ebi.ac.uk/pdbsum/6k5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k5r ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SUMO3_HUMAN SUMO3_HUMAN]] Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.<ref>PMID:11451954</ref> <ref>PMID:18538659</ref> [[http://www.uniprot.org/uniprot/VIE2_HCMVA VIE2_HCMVA]] Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection. In addition, activates quiescent cells to reenter the cell cycle and upregulates several E2F-responsive genes, which are responsible for pushing the cell into S phase. In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression.<ref>PMID:10516036</ref> <ref>PMID:19812159</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Chatterjee, K S]] | |||
[[Category: Das, R]] | |||
[[Category: Complex]] | |||
[[Category: Protein binding-transcription complex]] | |||