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==Crystal structure of IMP-1 metallo-beta-lactamase in a complex with MCR== | |||
<StructureSection load='6jed' size='340' side='right'caption='[[6jed]], [[Resolution|resolution]] 1.57Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jed]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JED FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MCR:SULFANYLACETIC+ACID'>MCR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jed OCA], [http://pdbe.org/6jed PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jed RCSB], [http://www.ebi.ac.uk/pdbsum/6jed PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jed ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Large Structures]] | |||
[[Category: Wachino, J]] | [[Category: Wachino, J]] | ||
[[Category: Hydrolase]] | |||
[[Category: Metallo-beta-lactamase]] | |||
Revision as of 08:51, 7 August 2019
Crystal structure of IMP-1 metallo-beta-lactamase in a complex with MCRCrystal structure of IMP-1 metallo-beta-lactamase in a complex with MCR
Structural highlights
Function[BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems. |
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