6geo: Difference between revisions

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-'''Unreleased structure'''
-The entry 6geo is ON HOLD
+==Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121A1 in complex with Triazole Pyrazole inhibitor 10j==
+<StructureSection load='6geo' size='340' side='right'caption='[[6geo]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Levy, C.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6geo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GEO FirstGlance]. <br>
-Description: Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121A1 in complex with Triazole Pyrazole inhibitor 10j
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EW2:2-chloranyl-3-[4-(imidazol-1-ylmethyl)-1-phenyl-pyrazol-3-yl]-1~{H}-indole'>EW2</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mycocyclosin_synthase Mycocyclosin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.21.9 1.14.21.9] </span></td></tr>
-[[Category: Levy, C.W]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6geo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6geo OCA], [http://pdbe.org/6geo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6geo RCSB], [http://www.ebi.ac.uk/pdbsum/6geo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6geo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CP121_MYCTO CP121_MYCTO]] Catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosin. Can also use cyclo(L-Tyr-L-Phe) (cYF), cyclo(L-Tyr-L-Trp) (cYW) and cyclo(L-Tyr-L-3,4-dihydroxyphenylalanine) (cY-DOPA) as substrate (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycocyclosin synthase]]
+[[Category: Levy, C W]]
+[[Category: Antibiotic]]
+[[Category: Inhibitor complex p450]]
+[[Category: Oxidoreductase]]