2g9c: Difference between revisions
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==Modified pyrimidines Specifically bind the purine riboswitch== | ==Modified pyrimidines Specifically bind the purine riboswitch== | ||
<StructureSection load='2g9c' size='340' side='right' caption='[[2g9c]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2g9c' size='340' side='right'caption='[[2g9c]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2g9c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9C FirstGlance]. <br> | <table><tr><td colspan='2'>[[2g9c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9C FirstGlance]. <br> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Batey, R T]] | [[Category: Batey, R T]] | ||
[[Category: Gilbert, S D]] | [[Category: Gilbert, S D]] | ||
Revision as of 12:32, 24 July 2019
Modified pyrimidines Specifically bind the purine riboswitchModified pyrimidines Specifically bind the purine riboswitch
Structural highlights
Publication Abstract from PubMedThe purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized. Modified pyrimidines specifically bind the purine riboswitch.,Gilbert SD, Mediatore SJ, Batey RT J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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