1z4u: Difference between revisions
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==hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585== | ==hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585== | ||
<StructureSection load='1z4u' size='340' side='right' caption='[[1z4u]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='1z4u' size='340' side='right'caption='[[1z4u]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1z4u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4U FirstGlance]. <br> | <table><tr><td colspan='2'>[[1z4u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z4U FirstGlance]. <br> | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4u_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4u_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Anstadt, R]] | [[Category: Anstadt, R]] | ||
Revision as of 12:09, 24 July 2019
hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedA novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds. Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid.,Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:15911260[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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