Hemagglutinin-esterase: Difference between revisions

Latest revision as of 11:23, 24 July 2019

Function

Hemagglutinin-esterase (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor - a sialic acid derivative. The esterase region of the HE is responsible for the destruction of the receptor^[1].

Structural highlights

The biological assmebly of HE is a and each monomer contains . The receptor binding site of HE is located at five exposed surface loops. . HE contains a ^[2].

3D structures of hemagglutinin-esterase

Hemagglutinin-esterase 3D structures

Pig torovirus glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate 3i1l

Drag the structure with the mouse to rotate

ReferencesReferences

↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
↑ Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8

[2] Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492

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@@ Line 11: / Line 11: @@
 </StructureSection>
-==3D structures of hemagglutinin-esterase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Hemagglutinin-esterase
-**[[3cl4]] – bcvHE – bovine corona virus<br />
-**[[3i1k]] – PtHE (mutant) – porcine torovirus<br />
-**[[3i26]] – BtHE – bovine torovirus<br />
-**[[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br />
-**[[5t9y]], [[5t96]] – savHE – salmon anemia virus<br />
-**[[5n11]] – HE – human corona virus<br />
-**[[5jif]] – HE – murine corona virus<br />
-**[[4zxn]] – rcvHE (mutant) – rat coronavirus<br />
-**[[5e64]] – IdvHE – Influenza D virus<br />
-**[[5e5w]] – IdvHE (mutant) <br />
-*Hemagglutinin-esterase complex
-**[[3cl5]] – bcvHE (mutant) + receptor<br />
-**[[3i1l]] – PtHE (mutant) + receptor<br />
-**[[3i27]] – BtHE + receptor<br />
-**[[4c7w]] – mhvHE (mutant) + receptor<br />
-**[[5t9y]] – savHE – salmon anemia virus<br />
-**[[5jil]] – rcvHE (mutant) + sialic acid derivative <br />
-**[[5e62]] – IdvHE + glucopyranoside derivative<br />
-**[[5e66]] – IdvHE + receptor analog<br />
-**[[5e65]] – IdvHE (mutant) + receptor analog<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]