2uus: Difference between revisions
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==Crystal structure of the rat FGF1-sucrose octasulfate (SOS) complex.== | ==Crystal structure of the rat FGF1-sucrose octasulfate (SOS) complex.== | ||
<StructureSection load='2uus' size='340' side='right' caption='[[2uus]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2uus' size='340' side='right'caption='[[2uus]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2uus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UUS FirstGlance]. <br> | <table><tr><td colspan='2'>[[2uus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UUS FirstGlance]. <br> | ||
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==See Also== | ==See Also== | ||
*[[Fibroblast growth factor|Fibroblast growth factor]] | *[[Fibroblast growth factor|Fibroblast growth factor]] | ||
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | |||
[[Category: Berezin, V]] | [[Category: Berezin, V]] | ||
[[Category: Bock, E]] | [[Category: Bock, E]] | ||
Revision as of 10:35, 24 July 2019
Crystal structure of the rat FGF1-sucrose octasulfate (SOS) complex.Crystal structure of the rat FGF1-sucrose octasulfate (SOS) complex.
Structural highlights
Function[FGF1_RAT] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedFibroblast growth factors (FGFs) constitute a family of at least 23 structurally related heparin-binding proteins that are involved in regulation of cell growth, survival, differentiation and migration. Sucrose octasulfate (SOS), a chemical analogue of heparin, has been demonstrated to activate FGF signalling pathways. The structure of rat FGF1 crystallized in the presence of SOS has been determined at 2.2 A resolution. SOS-mediated dimerization of FGF1 was observed, which was further supported by gel-filtration experiments. The major contributors to the sulfate-binding sites in rat FGF1 are Lys113, Lys118, Arg122 and Lys128. An arginine at position 116 is a consensus residue in mammalian FGF molecules; however, it is a serine in rat FGF1. This difference may be important for SOS-mediated FGF1 dimerization in rat. Dimerization effect of sucrose octasulfate on rat FGF1.,Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt, 6):448-52. Epub 2008 May 16. PMID:18540049[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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