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| </StructureSection> | | </StructureSection> |
| ==3D Structure of Gyrase==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Gyrase Subunit A
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| **[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br />
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| **[[2y3p]], [[4ckl]] – EcGyrA N-terminal+simocylinone – ''Escherichia coli''<br />
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| **[[1ajb]] - EcGyrA N-terminal+novobiocin<br />
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| **[[4ckk]] - EcGyrA N-terminal<br />
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| **[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br />
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| **[[1x75]] – EcGyrA14+CcdB<br />
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| **[[4elz]] - GyrA fragment+CcdB – ''Vibrio fischeri''<br />
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| **[[3ilw]], [[3ifz]] - MtGyrA ATPase domain – ''Mycobacterium tuberculosis''<br />
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| **[[3uc1]], [[4g3n]] - MtGyrA C-terminal<br />
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| **[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br />
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| **[[3no0]] - GyrA C-terminal – ''Aquifex aeolicus''<br />
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| **[[3lpx]] – GyrA N-terminal – ''Colwellia psychrerithraea''<br />
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| **[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br />
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| **[[4ddq]] – GyrA – ''Bacillus subtilis''<br />
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| **[[6n1r]], [[6n1q]] – SpGyrA N-terminal – ''Streptococcus pneumoniae'' – Cryo EM<br />
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| **[[6n1p]] – SpGyrA N-terminal + DNA – Cryo EM<br />
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| **[[5ztj]] - SeGyrA C-terminal – ''Salmonella enterica''<br />
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| *Gyrase Subunit B
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| **[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]] – GyrB N-terminal residues 2-234 + inhibitor – ''Staphylococcus aureus''<br />
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| **[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB N-terminal + ligand<br />
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| **[[5npk]], [[5npp]] - SaGyrB residues 410-1491 + DNA<br />
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| **[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
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| **[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br />
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| **[[5zxm]] - SeGyrB N-terminal (mutant) <br />
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| **[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
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| **[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br />
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| **[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br />
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| **[[4duh]], [[4zvi]], [[5l3j]], [[6f8j]], [[4hyp]], [[6f86]], [[5z9q]], [[5z9p]], [[5z9b]], [[5z9e]], [[5z9f]], [[5z9l]], [[5z9m]], [[5z9n]], [[5z4o]], [[5z4h]] - EcGyrB N-terminal+ inhibitor<br />
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| **[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br />
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| **[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
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| **[[6f96]], [[6f94]] - EcGyrB N-terminal + inhibitor<br />
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| **[[1kij]] – TtGyrB N-terminal+ antibiotic – ''Thermus thermophilus''<br />
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| **[[6enh]], [[6eng]] - TtGyrB ATPase domain + coumarine derivative<br />
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| **[[4b6c]] - GyrB N-terminal – ''Mycobacterium smegmatis''<br />
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| **[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
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| **[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
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| **[[3zkb]], [[3zkd]] - MtGyrB N-terminal + AMPPNP<br />
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| **[[3zm7]] - MtGyrB N-terminal + AMPPCP<br />
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| **[[4bae]] - MtGyrB N-terminal (mutant) + inhibitor<br />
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| *Gyrase Subunit A+Subunit B
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| **[[2xco]], [[2xcq]] - SaGyrB C-terminal/SaGyrA N-terminal <br />
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| **[[4plb]] - SaGyrB C-terminal/SaGyrA N-terminal +DNA<br />
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| **[[2xcr]], [[2xcs]], [[4bul]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant)+DNA<br />
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| **[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br />
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| **[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br />
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| **[[5cdn]], [[5cdo]], [[5cdp]], [[6fqv]] – SaGyrA + SaGyrB + DNA<br />
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| **[[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] – SaGyrA + SaGyrB + DNA + inhibitor<br />
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| **[[5cdq]], [[6fqm]], [[6fqs]] - SaGyrB + GyrA + DNA + antibiotic<br />
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| **[[5bs3]], [[5iwi]], [[5iwm]] - SaGyrB + GyrA + DNA + inhibitor<br />
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| **[[6fm4]] - SaGyrB (mutant) + GyrA + DNA + inhibitor<br />
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| **[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br />
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| **[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br />
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| **[[4z2c]], [[4z2d]] - SpGyrB + GyrA + DNA – ''Streptococcus pneumoniae''<br />
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| **[[4z2e]] - SpGyrB + GyrA + DNA + antibiotic<br />
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| **[[6gav]], [[6gau]] - MtGyrB + GyrA <br />
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| **[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br />
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| **[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br />
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| **[[3nuh]] – EcGyrA+EcGyrB<br />
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| *Reverse Gyrase
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| **[[1gku]] – AfTop-RG – ''Archaeoglobus fulgidus''<br />
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| **[[1gl9]] - AfTop-RG+ADPNP<br />
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| **[[3oiy]], [[3p4y]] – TmTop-RG helicase domain – ''Thermotoga maritima''<br />
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| **[[4ddt]], [[4ddu]], [[4ddv]], [[4ddw]], [[4ddx]] - TmTop-RG
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| }}
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| ==Additional Resources== | | ==Additional Resources== |
| For additional information, see: [[Bacterial Infections]] | | For additional information, see: [[Bacterial Infections]] |