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== Structural highlights ==
== Structural highlights ==
<scene name='41/410321/Cv/5'>Gyrase subunit A N-terminal and subunit B C-terminal complex with DNA and inhibitor</scene>. A <scene name='41/410321/Cv/6'>potential drug interacts with both DNA strands and in the hydrophobic pocket between subunits A and B</scene><ref>PMID:24900889</ref>. Water molecules shown as red spheres.
<scene name='41/410321/Cv/5'>Gyrase subunit A N-terminal and subunit B C-terminal complex with DNA and inhibitor</scene>. A <scene name='41/410321/Cv/6'>potential drug interacts with both DNA strands and in the hydrophobic pocket between subunits A and B</scene><ref>PMID:24900889</ref>. Water molecules shown as red spheres.
==3D Structure of Gyrase==
[[Gyrase 3D Structures]]
</StructureSection>
</StructureSection>
==3D Structure of Gyrase==
==3D Structure of Gyrase==
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**[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br />
**[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br />
**[[4ddq]] – GyrA – ''Bacillus subtilis''<br />
**[[4ddq]] – GyrA – ''Bacillus subtilis''<br />
**[[6n1r]], [[6n1q]] – SpGyrA N-terminal – ''Streptococcus pneumoniae'' – Cryo EM<br />
**[[6n1p]] – SpGyrA N-terminal + DNA – Cryo EM<br />
**[[5ztj]] - SeGyrA C-terminal – ''Salmonella enterica''<br />


*Gyrase Subunit B
*Gyrase Subunit B


**[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]] – GyrB ATP-binding domain residues 2-234 + inhibitor – ''Staphylococcus aureus''<br />
**[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]] – GyrB N-terminal residues 2-234 + inhibitor – ''Staphylococcus aureus''<br />
**[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB ATP-binding domain + ligand<br />
**[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB N-terminal + ligand<br />
**[[5npk]], [[5npp]] - SaGyrB residues 410-1491 + DNA<br />
**[[5npk]], [[5npp]] - SaGyrB residues 410-1491 + DNA<br />
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB ATP-binding domain + antibacterial<br />
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
**[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br />
**[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br />
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
**[[5zxm]] - SeGyrB N-terminal (mutant) <br />
**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
**[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br />
**[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br />
**[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br />
**[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br />
**[[4duh]], [[4zvi]], [[5l3j]] - EcGyrB N-terminal+ inhibitor<br />
**[[4duh]], [[4zvi]], [[5l3j]], [[6f8j]], [[4hyp]], [[6f86]], [[5z9q]], [[5z9p]], [[5z9b]], [[5z9e]], [[5z9f]], [[5z9l]], [[5z9m]], [[5z9n]], [[5z4o]], [[5z4h]] - EcGyrB N-terminal+ inhibitor<br />
**[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br />
**[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br />
**[[4hyp]] - EcGyrB residues 15-220 + inhibitor<br />
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
**[[1kij]] – GyrB ATPase domain+ antibiotic – ''Thermus thermophilus''<br />
**[[6f96]], [[6f94]] - EcGyrB N-terminal + inhibitor<br />
**[[4b6c]] - GyrB ATPase domain – ''Mycobacterium smegmatis''<br />
**[[1kij]] – TtGyrB N-terminal+ antibiotic – ''Thermus thermophilus''<br />
**[[6enh]], [[6eng]] - TtGyrB ATPase domain + coumarine derivative<br />
**[[4b6c]] - GyrB N-terminal – ''Mycobacterium smegmatis''<br />
**[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
**[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
**[[3zkb]], [[3zkd]] - MtGyrB ATPase domain + AMPPNP<br />
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
**[[3zm7]] - MtGyrB ATPase domain + AMPPCP<br />
**[[3zkb]], [[3zkd]] - MtGyrB N-terminal + AMPPNP<br />
**[[4bae]] - MtGyrB ATPase domain (mutant) + inhibitor<br />
**[[3zm7]] - MtGyrB N-terminal + AMPPCP<br />
**[[4bae]] - MtGyrB N-terminal (mutant) + inhibitor<br />


*Gyrase Subunit A+Subunit B
*Gyrase Subunit A+Subunit B
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**[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br />
**[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br />
**[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br />
**[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br />
**[[3nuh]] – EcGyrA+EcGyrB<br />
**[[5cdn]], [[5cdo]], [[5cdp]], [[6fqv]] – SaGyrA + SaGyrB + DNA<br />
**[[5cdn]], [[5cdo]], [[5cdp]], [[6fqv]] – SaGyrA + SaGyrB + DNA<br />
**[[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] – SaGyrA + SaGyrB + DNA + inhibitor<br />
**[[5cdq]], [[6fqm]], [[6fqs]] - SaGyrB + GyrA + DNA + antibiotic<br />
**[[5cdq]], [[6fqm]], [[6fqs]] - SaGyrB + GyrA + DNA + antibiotic<br />
**[[5bs3]], [[5iwi]], [[5iwm]] - SaGyrB + GyrA + DNA + inhibitor<br />
**[[6fm4]] - SaGyrB (mutant) + GyrA + DNA + inhibitor<br />
**[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br />
**[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br />
**[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br />
**[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br />
**[[4z2c]], [[4z2d]] - SpGyrB + GyrA + DNA – ''Streptococcus pneumoniae''<br />
**[[4z2c]], [[4z2d]] - SpGyrB + GyrA + DNA – ''Streptococcus pneumoniae''<br />
**[[4z2e]] - SpGyrB + GyrA + DNA + antibiotic<br />
**[[4z2e]] - SpGyrB + GyrA + DNA + antibiotic<br />
**[[5bs3]], [[5iwi]], [[5iwm]] - SaGyrB + GyrA + DNA + inhibitor<br />
**[[6gav]], [[6gau]] - MtGyrB + GyrA <br />
**[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br />
**[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br />
**[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br />
**[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br />
**[[3nuh]] – EcGyrA+EcGyrB<br />


*Reverse Gyrase
*Reverse Gyrase

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Alexander Berchansky, Michal Harel, Joel L. Sussman
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