1mnc: Difference between revisions
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==STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET== | ==STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET== | ||
<StructureSection load='1mnc' size='340' side='right' caption='[[1mnc]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1mnc' size='340' side='right'caption='[[1mnc]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mnc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MNC FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mnc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MNC FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1mnc" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1mnc" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Matrix metalloproteinase|Matrix metalloproteinase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Interstitial collagenase]] | [[Category: Interstitial collagenase]] | ||
[[Category: Large Structures]] | |||
[[Category: Rubin, B]] | [[Category: Rubin, B]] | ||
[[Category: Smith, D L]] | [[Category: Smith, D L]] | ||
[[Category: Spurlino, J C]] | [[Category: Spurlino, J C]] | ||
[[Category: Stams, T]] | [[Category: Stams, T]] | ||
Revision as of 13:58, 17 July 2019
STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKETSTRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET
Structural highlights
Function[MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystal structure of the catalytic domain of human neutrophil collagenase complexed with a peptide transition state analogue has been determined to a resolution of 2.1 A. The structure of the neutrophil enzyme, when compared with the three dimensional structure of the corresponding human fibroblast collagenase, shows differences in the first, S1', of the three enzyme specificity subsites on the carboxy-terminal side of the substrate scissile bond. The S1' pocket in the neutrophil collagenase is significantly larger than the equivalent site in the fibroblast enzyme, suggesting that the former enzyme has a broader range of possible substrates. Such differences also suggest approaches for the design of selective matrix metalloproteinase inhibitors. Structure of human neutrophil collagenase reveals large S1' specificity pocket.,Stams T, Spurlino JC, Smith DL, Wahl RC, Ho TF, Qoronfleh MW, Banks TM, Rubin B Nat Struct Biol. 1994 Feb;1(2):119-23. PMID:7656015[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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