6nnh: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nnh is ON HOLD
+==Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil==
+<StructureSection load='6nnh' size='340' side='right'caption='[[6nnh]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
-Authors: Giudice, J.H.P., Ribeiro, J.A., Dias, M.V.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nnh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NNH FirstGlance]. <br>
-Description: Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-[[Category: Ribeiro, J.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nnh OCA], [http://pdbe.org/6nnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nnh RCSB], [http://www.ebi.ac.uk/pdbsum/6nnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nnh ProSAT]</span></td></tr>
-[[Category: Dias, M.V.B]]
+</table>
-[[Category: Giudice, J.H.P]]
+== Function ==
+[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
+__TOC__
+</StructureSection>
+[[Category: Dihydrofolate reductase]]
+[[Category: Large Structures]]
+[[Category: Dias, M V.B]]
+[[Category: Giudice, J H.P]]
+[[Category: Ribeiro, J A]]
+[[Category: Antifolate]]
+[[Category: Biosynthetic protein]]