6mq7: Difference between revisions

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-'''Unreleased structure'''
-The entry 6mq7 is ON HOLD  until Oct 09 2020
+==Crystal structure of CLASP1 TOG2 domain at 1.78A resolution==
+<StructureSection load='6mq7' size='340' side='right'caption='[[6mq7]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
-Authors: Leano, J.B., Slep, K.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mq7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQ7 FirstGlance]. <br>
-Description: Crystal structure of CLASP1 TOG2 domain at 1.78A resolution
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mq5|6mq5]], [[4k92|4k92]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mq7 OCA], [http://pdbe.org/6mq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mq7 RCSB], [http://www.ebi.ac.uk/pdbsum/6mq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mq7 ProSAT]</span></td></tr>
-[[Category: Leano, J.B]]
+</table>
-[[Category: Slep, K.C]]
+== Function ==
+[[http://www.uniprot.org/uniprot/CLAP1_HUMAN CLAP1_HUMAN]] Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.<ref>PMID:11290329</ref> <ref>PMID:12837247</ref> <ref>PMID:15631994</ref> <ref>PMID:16866869</ref> <ref>PMID:16914514</ref> <ref>PMID:17543864</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Leano, J B]]
+[[Category: Slep, K C]]
+[[Category: Microtubule binding protein]]
+[[Category: Structural protein]]