Glucocorticoid receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD) residues 417-506; hinge region; ligand-binding domain (LBD) residues 521-777 and C terminal domain.
+==3D structures of glucocorticoid receptor==
+[[Glucocorticoid receptor 3D structures]]
 </StructureSection>
 ==3D structures of glucocorticoid receptor==
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 *Glucocorticoid receptor DBD domain residues 391-480
+**[[6cfn]] - hGCR DBD <br />
+**[[4hn5]], [[4hn6]], [[5emp]], [[5emq]], [[5emc]], [[5e69]], [[5e6a]], [[5e6b]], [[5e6c]], [[5e6d]], [[5cbx]], [[5cby]], [[5cbz]], [[6bqu]] - hGCR DBD + DNA<br />
+**[[5cc1]] - hGCR DBD (mutant) + DNA <br />
 **[[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br />
 **[[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br />
-**[[4hn5]], [[4hn6]], [[5emp]], [[5emq]], [[5emc]], [[5e69]], [[5e6a]], [[5e6b]], [[5e6c]], [[5e6d]], [[5cbx]], [[5cby]], [[5cbz]] - hGCR DBD + DNA – human<br />
-**[[5cc1]] - hGCR DBD (mutant) + DNA <br />
 *Glucocorticoid receptor LBD domain residues 500-777 complex with NCOA peptide
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 **[[5uc3]] - hGCR LBD (mutant) + RU-486<br />
 **[[3k22]] - hGCR LBD (mutant) + transcriptional intermediary factor 2  peptide + alaninamide<br />
+**[[6dxk]] – hGCR LBD + antagonist<br />
 *Glucocorticoid receptor 2