Macrophage inhibitory factor: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
MIF contains two different catalytic sites.  A phenylpyruvate tautomerase site is located in the N terminal.  A <scene name='55/551208/Cv/2'>disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60</scene>.  The <scene name='55/551208/Cv/4'>inhibitor binds to the pro-inflammatory tautomerase site</scene><ref>PMID:17526494</ref>. Water molecules shown as red spheres.
MIF contains two different catalytic sites.  A phenylpyruvate tautomerase site is located in the N terminal.  A <scene name='55/551208/Cv/5'>disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60</scene>.  The <scene name='55/551208/Cv/6'>inhibitor binds to the pro-inflammatory tautomerase site</scene><ref>PMID:17526494</ref>. Water molecules shown as red spheres.
</StructureSection>
</StructureSection>


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Michal Harel, Alexander Berchansky