Flagellin: Difference between revisions
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<scene name='77/776389/Cv/2'>Fla and TLR5 binding interface is composed in part between the long helices of Fla and the ascending lateral surface of TLR5</scene><ref>PMID:22344444</ref>. | <scene name='77/776389/Cv/2'>Fla and TLR5 binding interface is composed in part between the long helices of Fla and the ascending lateral surface of TLR5</scene><ref>PMID:22344444</ref>. | ||
== 3D Structures of flagellin == | |||
[[Flagellin 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of flagellin == | == 3D Structures of flagellin == | ||
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**[[5wjt]], [[5wju]], [[5wjv]], [[5wjw]], [[5wjx]], [[5wjy]], [[5wjz]] – BsFla – ''Bacillus subtilis'' – Cryo EM<br /> | **[[5wjt]], [[5wju]], [[5wjv]], [[5wjw]], [[5wjx]], [[5wjy]], [[5wjz]] – BsFla – ''Bacillus subtilis'' – Cryo EM<br /> | ||
**[[2zbi]] – Fla - ''Sphingomonas''<br /> | **[[2zbi]] – Fla - ''Sphingomonas''<br /> | ||
**[[5z7q]] – Fla residues 54-229 – ''Bacillus cereus'' <br /> | |||
**[[5z1l]] – Fla – ''Methanococcus maripaludis'' – Cryo EM<br /> | |||
* Flagellin complex | * Flagellin complex | ||
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**[[3v47]] – Fla phase1 + TLR5 – ''Salmonella enterica''<br /> | **[[3v47]] – Fla phase1 + TLR5 – ''Salmonella enterica''<br /> | ||
**[[5gy2]] – BsFla residues 54-230 + TLR5 <br /> | **[[5gy2]] – BsFla residues 54-230 + TLR5 <br /> | ||
**[[6gow]], [[5maw]] – BsFla + FliS <br /> | |||
**[[1ory]] – AaFla FliC residues 464-518 + FliS <br /> | **[[1ory]] – AaFla FliC residues 464-518 + FliS <br /> | ||
**[[5yud]] – StFla + Naip5 <br /> | **[[5yud]] – StFla + Naip5 <br /> | ||
Revision as of 09:36, 3 July 2019
FunctionFlagellin (Fla) from Salmonella typhimurium is the major molecular trigger by which the pathogen activates gut epithelial proinflammatory gene expression[1]. Toll-like receptor 5 (TLR5) recognizes bacterial Fla and this association mediates the innate immune response to the bacteria[2].
Structural highlights[3]. 3D Structures of flagellin
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3D Structures of flagellin3D Structures of flagellin
Updated on 03-July-2019
ReferencesReferences
- ↑ Zeng H, Carlson AQ, Guo Y, Yu Y, Collier-Hyams LS, Madara JL, Gewirtz AT, Neish AS. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol. 2003 Oct 1;171(7):3668-74. PMID:14500664
- ↑ Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106
- ↑ Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science. 2012 Feb 17;335(6070):859-64. PMID:22344444 doi:10.1126/science.1215584