5zoi: Difference between revisions

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'''Unreleased structure'''


The entry 5zoi is ON HOLD  until Jun 22 2020
==Crystal Structure of alpha1,3-Fucosyltransferase==
 
<StructureSection load='5zoi' size='340' side='right'caption='[[5zoi]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
Authors: Tan, Y., Yang, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5zoi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZOI FirstGlance]. <br>
Description: Crystal Structure of alpha1,3-Fucosyltransferase
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C06:[[(2S,3R,4S,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2S,3S,4S,5R,6R)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]+hydrogen+phosphate'>C06</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-galactosyl-N-acetylglucosaminide_3-alpha-L-fucosyltransferase 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.152 2.4.1.152] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zoi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zoi OCA], [http://pdbe.org/5zoi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zoi RCSB], [http://www.ebi.ac.uk/pdbsum/5zoi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zoi ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FUCT_HELPX FUCT_HELPX]] Involved in the biosynthesis of the Lewis X (LeX) trisaccharide of the lipopolysaccharide (LPS) O-antigen. Catalyzes the addition of fucose in alpha 1-3 linkage to Gal-beta-1-4-GlcNAc-beta-O-R (LacNAc-R) type II acceptor.<ref>PMID:12676935</ref> <ref>PMID:16150700</ref> <ref>PMID:16800635</ref> <ref>PMID:17251184</ref> <ref>PMID:9261149</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase]]
[[Category: Large Structures]]
[[Category: Tan, Y]]
[[Category: Tan, Y]]
[[Category: Yang, G]]
[[Category: Yang, G]]
[[Category: Enzyme]]
[[Category: Transferase]]

Revision as of 09:41, 26 June 2019

Crystal Structure of alpha1,3-FucosyltransferaseCrystal Structure of alpha1,3-Fucosyltransferase

Structural highlights

5zoi is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, with EC number 2.4.1.152
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FUCT_HELPX] Involved in the biosynthesis of the Lewis X (LeX) trisaccharide of the lipopolysaccharide (LPS) O-antigen. Catalyzes the addition of fucose in alpha 1-3 linkage to Gal-beta-1-4-GlcNAc-beta-O-R (LacNAc-R) type II acceptor.[1] [2] [3] [4] [5]

References

  1. ↑ Ma B, Wang G, Palcic MM, Hazes B, Taylor DE. C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer. J Biol Chem. 2003 Jun 13;278(24):21893-900. doi: 10.1074/jbc.M301704200. Epub, 2003 Apr 3. PMID:12676935 doi:http://dx.doi.org/10.1074/jbc.M301704200
  2. ↑ Ma B, Lau LH, Palcic MM, Hazes B, Taylor DE. A single aromatic amino acid at the carboxyl terminus of Helicobacter pylori {alpha}1,3/4 fucosyltransferase determines substrate specificity. J Biol Chem. 2005 Nov 4;280(44):36848-56. doi: 10.1074/jbc.M504415200. Epub 2005 , Sep 2. PMID:16150700 doi:http://dx.doi.org/10.1074/jbc.M504415200
  3. ↑ Lin SW, Yuan TM, Li JR, Lin CH. Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability. Biochemistry. 2006 Jul 4;45(26):8108-16. doi: 10.1021/bi0601297. PMID:16800635 doi:http://dx.doi.org/10.1021/bi0601297
  4. ↑ Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH. Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design. J Biol Chem. 2007 Mar 30;282(13):9973-82. Epub 2007 Jan 24. PMID:17251184 doi:http://dx.doi.org/10.1074/jbc.M610285200
  5. ↑ Ge Z, Chan NW, Palcic MM, Taylor DE. Cloning and heterologous expression of an alpha1,3-fucosyltransferase gene from the gastric pathogen Helicobacter pylori. J Biol Chem. 1997 Aug 22;272(34):21357-63. PMID:9261149

5zoi, resolution 3.19Å

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