Exophilin: Difference between revisions
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'''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 ions and phospholipids are involved in synaptic vesicle docking. | '''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 ions and phospholipids are involved in synaptic vesicle docking. | ||
* EXP-1 or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | * '''EXP-1''' or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | ||
* EXP-2 or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br /> | * '''EXP-2''' or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br /> | ||
* EXP-3 or '''melanophilin''' links [[Myosin]] Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity<ref>PMID:15760894</ref>.<br /> | * '''EXP-3''' or '''melanophilin''' links [[Myosin]] Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity<ref>PMID:15760894</ref>.<br /> | ||
== Relevance == | == Relevance == | ||