4z02: Difference between revisions

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==Crystal structure of BRD1 in complex with Isoquinoline-3-carboxylic acid==
==Crystal structure of BRD1 in complex with Isoquinoline-3-carboxylic acid==
<StructureSection load='4z02' size='340' side='right' caption='[[4z02]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='4z02' size='340' side='right'caption='[[4z02]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4z02]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z02 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4z02]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z02 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4K8:ISOQUINOLINE-3-CARBOXYLIC+ACID'>4K8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4K8:ISOQUINOLINE-3-CARBOXYLIC+ACID'>4K8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD1, BRL, BRPF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z02 OCA], [http://pdbe.org/4z02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z02 RCSB], [http://www.ebi.ac.uk/pdbsum/4z02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z02 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z02 OCA], [http://pdbe.org/4z02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z02 RCSB], [http://www.ebi.ac.uk/pdbsum/4z02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z02 ProSAT]</span></td></tr>
</table>
</table>
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==See Also==
==See Also==
*[[Bromodomain-containing protein|Bromodomain-containing protein]]
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H]]
[[Category: BROWN, P J]]
[[Category: BROWN, P J]]

Revision as of 10:09, 19 June 2019

Crystal structure of BRD1 in complex with Isoquinoline-3-carboxylic acidCrystal structure of BRD1 in complex with Isoquinoline-3-carboxylic acid

Structural highlights

4z02 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:BRD1, BRL, BRPF2 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

See Also

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

4z02, resolution 1.87Å

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