DNA polymerase: Difference between revisions
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Polymerase η, Polymerase ι, and Polymerase κ are Family Y DNA polymerases involved in the DNA repair by '''translesion synthesis'''. Polymerases in Family Y are prone to errors during DNA synthesis. Pol η is important for the accurate translesion synthesis of DNA damage resulting from ultraviolet radiation. The function of Pol κ is not completely understood, but it is thought to act as an extender or inserter of a specific base at certain DNA lesions. All three translesion synthesis polymerases are activated by stalled replicative DNA polymerases.<ref name="ncbi" /> | Polymerase η, Polymerase ι, and Polymerase κ are Family Y DNA polymerases involved in the DNA repair by '''translesion synthesis'''. Polymerases in Family Y are prone to errors during DNA synthesis. Pol η is important for the accurate translesion synthesis of DNA damage resulting from ultraviolet radiation. The function of Pol κ is not completely understood, but it is thought to act as an extender or inserter of a specific base at certain DNA lesions. All three translesion synthesis polymerases are activated by stalled replicative DNA polymerases.<ref name="ncbi" /> | ||
====Terminal deoxynucleotidyl transferase==== | |||
TdT catalyzes the polymerization of deoxynucleoside triphophates to the 3'-hydroxyl group of preformed polynucleotide chain. TdT is a non-template directed DNA polymerase and was detected in thymus glands<ref>PMID:12170602</ref>. | |||
===Prokaryotic Polymerase=== | ===Prokaryotic Polymerase=== | ||