4yps: Difference between revisions
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==(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors== | ==(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors== | ||
<StructureSection load='4yps' size='340' side='right' caption='[[4yps]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4yps' size='340' side='right'caption='[[4yps]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4yps]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YPS FirstGlance]. <br> | <table><tr><td colspan='2'>[[4yps]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YPS FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4F6:4-{6-[(3R)-3-(3-FLUOROPHENYL)MORPHOLIN-4-YL]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}BENZONITRILE'>4F6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4F6:4-{6-[(3R)-3-(3-FLUOROPHENYL)MORPHOLIN-4-YL]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}BENZONITRILE'>4F6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yne|4yne]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yne|4yne]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NTRK1, MTC, TRK, TRKA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yps OCA], [http://pdbe.org/4yps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yps RCSB], [http://www.ebi.ac.uk/pdbsum/4yps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yps ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yps OCA], [http://pdbe.org/4yps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yps RCSB], [http://www.ebi.ac.uk/pdbsum/4yps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yps ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4yps" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4yps" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[High affinity nerve growth factor receptor|High affinity nerve growth factor receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
[[Category: Kreusch, A]] | [[Category: Kreusch, A]] | ||