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==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds== | ==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds== | ||
<StructureSection load='4yqb' size='340' side='right' caption='[[4yqb]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4yqb' size='340' side='right'caption='[[4yqb]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4yqb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQB FirstGlance]. <br> | <table><tr><td colspan='2'>[[4yqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haein Haein]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQB FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GM:6-[(2-HYDROXYBENZYL)AMINO]PYRIDINE-3-CARBOXAMIDE'>4GM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GM:6-[(2-HYDROXYBENZYL)AMINO]PYRIDINE-3-CARBOXAMIDE'>4GM</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ypw|4ypw]], [[4ypx|4ypx]], [[4ypz|4ypz]], [[4yq0|4yq0]], [[4yq1|4yq1]], [[4yq2|4yq2]], [[4yq3|4yq3]], [[4yq4|4yq4]], [[4yq5|4yq5]], [[4yq6|4yq6]], [[4yq7|4yq7]], [[4yq8|4yq8]], [[4yq9|4yq9]], [[4yqa|4yqa]], [[4yqc|4yqc]], [[4yqd|4yqd]], [[4yqg|4yqg]], [[4yqi|4yqi]], [[4yqj|4yqj]], [[4yqk|4yqk]], [[4yql|4yql]], [[4yqn|4yqn]], [[4yqo|4yqo]], [[4yqp|4yqp]], [[4yqq|4yqq]], [[4yqr|4yqr]], [[4yqs|4yqs]], [[4yqt|4yqt]], [[4ypy|4ypy]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ypw|4ypw]], [[4ypx|4ypx]], [[4ypz|4ypz]], [[4yq0|4yq0]], [[4yq1|4yq1]], [[4yq2|4yq2]], [[4yq3|4yq3]], [[4yq4|4yq4]], [[4yq5|4yq5]], [[4yq6|4yq6]], [[4yq7|4yq7]], [[4yq8|4yq8]], [[4yq9|4yq9]], [[4yqa|4yqa]], [[4yqc|4yqc]], [[4yqd|4yqd]], [[4yqg|4yqg]], [[4yqi|4yqi]], [[4yqj|4yqj]], [[4yqk|4yqk]], [[4yql|4yql]], [[4yqn|4yqn]], [[4yqo|4yqo]], [[4yqp|4yqp]], [[4yqq|4yqq]], [[4yqr|4yqr]], [[4yqs|4yqs]], [[4yqt|4yqt]], [[4ypy|4ypy]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trmD, HI_0202 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 HAEIN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqb OCA], [http://pdbe.org/4yqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqb RCSB], [http://www.ebi.ac.uk/pdbsum/4yqb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqb OCA], [http://pdbe.org/4yqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqb RCSB], [http://www.ebi.ac.uk/pdbsum/4yqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605] | [[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605] | ||
==See Also== | |||
*[[TRNA methyltransferase|TRNA methyltransferase]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Haein]] | |||
[[Category: Large Structures]] | |||
[[Category: Bonnette, W G]] | [[Category: Bonnette, W G]] | ||
[[Category: Elkins, P A]] | [[Category: Elkins, P A]] | ||
Revision as of 09:33, 12 June 2019
Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compoundsCrystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds
Structural highlights
Function[TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605] See Also |
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