6fdm: Difference between revisions

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==Human Rio2 kinase structure==
==Human Rio2 kinase structure==
<StructureSection load='6fdm' size='340' side='right' caption='[[6fdm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='6fdm' size='340' side='right'caption='[[6fdm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fdm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FDM FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fdm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FDM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIOK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fdm OCA], [http://pdbe.org/6fdm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fdm RCSB], [http://www.ebi.ac.uk/pdbsum/6fdm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fdm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fdm OCA], [http://pdbe.org/6fdm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fdm RCSB], [http://www.ebi.ac.uk/pdbsum/6fdm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fdm ProSAT]</span></td></tr>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: FRIBOURG, S]]
[[Category: Fribourg, S]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 09:10, 12 June 2019

Human Rio2 kinase structureHuman Rio2 kinase structure

Structural highlights

6fdm is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:RIOK2 (HUMAN)
Activity:Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RIOK2_HUMAN] Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).[1] [2] [3]

References

  1. ↑ Rouquette J, Choesmel V, Gleizes PE. Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells. EMBO J. 2005 Aug 17;24(16):2862-72. doi: 10.1038/sj.emboj.7600752. Epub 2005 Jul , 28. PMID:16037817 doi:http://dx.doi.org/10.1038/sj.emboj.7600752
  2. ↑ Zemp I, Wild T, O'Donohue MF, Wandrey F, Widmann B, Gleizes PE, Kutay U. Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. J Cell Biol. 2009 Jun 29;185(7):1167-80. PMID:19564402 doi:http://dx.doi.org/jcb.200904048
  3. ↑ Liu T, Deng M, Li J, Tong X, Wei Q, Ye X. Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. J Biol Chem. 2011 Oct 21;286(42):36352-60. doi: 10.1074/jbc.M111.250175. Epub, 2011 Aug 31. PMID:21880710 doi:http://dx.doi.org/10.1074/jbc.M111.250175

6fdm, resolution 2.10Å

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