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==Structure of human Mcl-1 in complex with thienopyrimidine inhibitor== | |||
<StructureSection load='6qgd' size='340' side='right'caption='[[6qgd]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qgd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QGD FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J1N:2-[(6-ethyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)amino]-3-oxidanyl-propanoic+acid'>J1N</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qfi|6qfi]], [[6qfm|6qfm]], [[6qfq|6qfq]]</td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qgd OCA], [http://pdbe.org/6qgd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qgd RCSB], [http://www.ebi.ac.uk/pdbsum/6qgd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qgd ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Casara, P]] | |||
[[Category: Chen, I]] | [[Category: Chen, I]] | ||
[[Category: Davidson, J]] | [[Category: Davidson, J]] | ||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
[[Category: Diguarher, T Le]] | |||
[[Category: Dokurno, P]] | |||
[[Category: Geneste, O]] | |||
[[Category: Graham, C J]] | |||
[[Category: Harris, R]] | |||
[[Category: Hickman, J]] | [[Category: Hickman, J]] | ||
[[Category: Hubbard, R E]] | |||
[[Category: Jordan, A M]] | |||
[[Category: Kotschy, A]] | |||
[[Category: Matassova, N]] | |||
[[Category: Murray, J]] | |||
[[Category: Pedder, C]] | |||
[[Category: Ray, S]] | |||
[[Category: Roughley, S]] | |||
[[Category: Smith, J]] | |||
[[Category: Stark, J]] | [[Category: Stark, J]] | ||
[[Category: Walmsley, C]] | |||
[[Category: Wang, Y]] | |||
[[Category: Whitehead, N]] | [[Category: Whitehead, N]] | ||
[[Category: | [[Category: Williamson, D S]] | ||
[[Category: Apoptosis]] | |||
[[Category: Mbp]] | |||
[[Category: | [[Category: Mcl1]] | ||
[[Category: | [[Category: Small molecule inhibitor]] | ||
[[Category: | |||
[[Category: | |||
Revision as of 08:46, 12 June 2019
Structure of human Mcl-1 in complex with thienopyrimidine inhibitorStructure of human Mcl-1 in complex with thienopyrimidine inhibitor
Structural highlights
Function[MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). |
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