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==Histidine-containing phosphocarrier protein (HPr) and antisigma factor Rsd complex== | ==Histidine-containing phosphocarrier protein (HPr) and antisigma factor Rsd complex== | ||
<StructureSection load='4xwj' size='340' side='right' caption='[[4xwj]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4xwj' size='340' side='right'caption='[[4xwj]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xwj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XWJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XWJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwj OCA], [http://pdbe.org/4xwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xwj RCSB], [http://www.ebi.ac.uk/pdbsum/4xwj PDBsum]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rsd, b3995, JW3959 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), ptsH, hpr, b2415, JW2408 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwj OCA], [http://pdbe.org/4xwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xwj RCSB], [http://www.ebi.ac.uk/pdbsum/4xwj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xwj ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RSD_ECOLI RSD_ECOLI]] Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.<ref>PMID:9560209</ref> <ref>PMID:10368152</ref> [[http://www.uniprot.org/uniprot/PTHP_ECOLI PTHP_ECOLI]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III). | [[http://www.uniprot.org/uniprot/RSD_ECOLI RSD_ECOLI]] Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.<ref>PMID:9560209</ref> <ref>PMID:10368152</ref> [[http://www.uniprot.org/uniprot/PTHP_ECOLI PTHP_ECOLI]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III). | ||
==See Also== | |||
*[[Phosphocarrier protein|Phosphocarrier protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Ecoli]] | |||
[[Category: Large Structures]] | |||
[[Category: Ha, N C]] | [[Category: Ha, N C]] | ||
[[Category: Seok, Y J]] | [[Category: Seok, Y J]] | ||
Revision as of 03:15, 6 June 2019
Histidine-containing phosphocarrier protein (HPr) and antisigma factor Rsd complexHistidine-containing phosphocarrier protein (HPr) and antisigma factor Rsd complex
Structural highlights
Function[RSD_ECOLI] Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.[1] [2] [PTHP_ECOLI] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III). See AlsoReferences
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