6aax: Difference between revisions

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'''Unreleased structure'''


The entry 6aax is ON HOLD  until Paper Publication
==Crystal structure of TFB1M and h45 with SAM in homo sapiens==
 
<StructureSection load='6aax' size='340' side='right'caption='[[6aax]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
Authors: Liu, X., Shen, S., Wu, P., Li, F., Gong, Q., Wu, J., Zhang, H., Shi, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6aax]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AAX FirstGlance]. <br>
Description: Crystal structure of TFB1M and h45 with SAM in homo sapiens
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aax OCA], [http://pdbe.org/6aax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aax RCSB], [http://www.ebi.ac.uk/pdbsum/6aax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aax ProSAT]</span></td></tr>
[[Category: Wu, J]]
</table>
[[Category: Zhang, H]]
== Disease ==
[[http://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN]] Mitochondrial non-syndromic sensorineural deafness. Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.  
== Function ==
[[http://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.<ref>PMID:11809803</ref> <ref>PMID:12068295</ref> <ref>PMID:12897151</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gong, Q]]
[[Category: Li, F]]
[[Category: Liu, X]]
[[Category: Liu, X]]
[[Category: Gong, Q]]
[[Category: Wu, P]]
[[Category: Shen, S]]
[[Category: Shen, S]]
[[Category: Li, F]]
[[Category: Shi, Y]]
[[Category: Shi, Y]]
[[Category: Wu, J]]
[[Category: Wu, P]]
[[Category: Zhang, H]]
[[Category: H45]]
[[Category: Tfb1m]]
[[Category: Transferase-rna complex]]

Revision as of 01:41, 6 June 2019

Crystal structure of TFB1M and h45 with SAM in homo sapiensCrystal structure of TFB1M and h45 with SAM in homo sapiens

Structural highlights

6aax is a 4 chain structure with sequence from [1] and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[TFB1M_HUMAN] Mitochondrial non-syndromic sensorineural deafness. Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.

Function

[TFB1M_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.[1] [2] [3]

References

  1. ↑ McCulloch V, Seidel-Rogol BL, Shadel GS. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol Cell Biol. 2002 Feb;22(4):1116-25. PMID:11809803
  2. ↑ Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat Genet. 2002 Jul;31(3):289-94. Epub 2002 Jun 17. PMID:12068295 doi:http://dx.doi.org/10.1038/ng909
  3. ↑ McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol. 2003 Aug;23(16):5816-24. PMID:12897151

6aax, resolution 2.99Å

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