Proteins from Mycobacterium tuberculosis: Difference between revisions
New page: <StructureSection load='' size='450' side='right' scene='80/801748/Cv/1' caption=''> === The structure of ''Mycobacterium tuberculosis'' HtrA reveals an auto-regulatory mechanism === <big... |
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<StructureSection load='' size='450' side='right' scene='80/801748/Cv/1' caption=''> | <StructureSection load='' size='450' side='right' scene='80/801748/Cv/1' caption=''> | ||
=== The structure of ''Mycobacterium tuberculosis'' HtrA reveals an auto-regulatory mechanism | === The structure of ''Mycobacterium tuberculosis'' HtrA reveals an auto-regulatory mechanism<ref>doi 10.1107/S2053230X18016217</ref> === | ||
There are three HtrA paralogues in ''M. tuberculosis'' viz., HtrA (Rv1223), PepD (Rv0983) and PepA (Rv0125). Among these, only HtrA is essential for bacterial survival. ''M. tuberculosis'' PepD participates in a two component signaling pathway involving MprAB and σ<sup>E</sup>. It has been suggested that recognition of misfolded proteins by the PDZ domain in PepD activates this pathway. However, unlike DegS, this HtrA homologue is constitutively active and the PDZ domain positively modulates its enzymatic activity. An aspect that is less explored in this context is the role of the N-terminal cytoplasmic domain. Both HtrA and PepD are predicted to have a cytoplasmic polypeptide stretch of 100-150 residues. | There are three HtrA paralogues in ''M. tuberculosis'' viz., HtrA (Rv1223), PepD (Rv0983) and PepA (Rv0125). Among these, only HtrA is essential for bacterial survival. ''M. tuberculosis'' PepD participates in a two component signaling pathway involving MprAB and σ<sup>E</sup>. It has been suggested that recognition of misfolded proteins by the PDZ domain in PepD activates this pathway. However, unlike DegS, this HtrA homologue is constitutively active and the PDZ domain positively modulates its enzymatic activity. An aspect that is less explored in this context is the role of the N-terminal cytoplasmic domain. Both HtrA and PepD are predicted to have a cytoplasmic polypeptide stretch of 100-150 residues. | ||