4uvq: Difference between revisions
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==PatG Domain of Unknown Function== | ==PatG Domain of Unknown Function== | ||
<StructureSection load='4uvq' size='340' side='right' caption='[[4uvq]], [[Resolution|resolution]] 1.72Å' scene=''> | <StructureSection load='4uvq' size='340' side='right'caption='[[4uvq]], [[Resolution|resolution]] 1.72Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4uvq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UVQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[4uvq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Prosc Prosc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UVQ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Prosc]] | |||
[[Category: Bent, A F]] | [[Category: Bent, A F]] | ||
[[Category: Graham, R]] | [[Category: Graham, R]] | ||
Revision as of 11:45, 23 May 2019
PatG Domain of Unknown FunctionPatG Domain of Unknown Function
Structural highlights
Publication Abstract from PubMedPatellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological `toolkit' to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated. The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster.,Mann G, Koehnke J, Bent AF, Graham R, Houssen W, Jaspars M, Schwarz-Linek U, Naismith JH Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1597-603. doi:, 10.1107/S2053230X1402425X. Epub 2014 Nov 14. PMID:25484206[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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