1hek: Difference between revisions
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==Crystal structure of equine infectious anaemia virus matrix antigen (EIAV MA)== | ==Crystal structure of equine infectious anaemia virus matrix antigen (EIAV MA)== | ||
<StructureSection load='1hek' size='340' side='right' caption='[[1hek]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='1hek' size='340' side='right'caption='[[1hek]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1hek]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HEK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1hek]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eiav Eiav]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HEK FirstGlance]. <br> | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1eia|1eia]], [[2eia|2eia]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1eia|1eia]], [[2eia|2eia]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11665 EIAV])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hek OCA], [http://pdbe.org/1hek PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hek RCSB], [http://www.ebi.ac.uk/pdbsum/1hek PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hek ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hek OCA], [http://pdbe.org/1hek PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hek RCSB], [http://www.ebi.ac.uk/pdbsum/1hek PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hek ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Eiav]] | |||
[[Category: Large Structures]] | |||
[[Category: Fry, E]] | [[Category: Fry, E]] | ||
[[Category: Hatanaka, H]] | [[Category: Hatanaka, H]] | ||
Revision as of 10:04, 23 May 2019
Crystal structure of equine infectious anaemia virus matrix antigen (EIAV MA)Crystal structure of equine infectious anaemia virus matrix antigen (EIAV MA)
Structural highlights
Publication Abstract from PubMedThe Gag polyprotein is key to the budding of retroviruses from host cells and is cleaved upon virion maturation, the N-terminal membrane-binding domain forming the matrix protein (MA). The 2.8-A resolution crystal structure of MA of equine infectious anemia virus (EIAV), a lentivirus, reveals that, despite showing no sequence similarity, more than half of the molecule can be superimposed on the MAs of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV). However, unlike the structures formed by HIV-1 and SIV MAs, the oligomerization state observed is not trimeric. We discuss the potential of this molecule for membrane binding in the light of conformational differences between EIAV MA and HIV or SIV MA. Structure of equine infectious anemia virus matrix protein.,Hatanaka H, Iourin O, Rao Z, Fry E, Kingsman A, Stuart DI J Virol. 2002 Feb;76(4):1876-83. PMID:11799182[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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