4uee: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH==
==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH==
<StructureSection load='4uee' size='340' side='right' caption='[[4uee]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
<StructureSection load='4uee' size='340' side='right'caption='[[4uee]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4uee]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UEE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4uee]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UEE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA9:(2S)-2-{[(R)-{(1R)-1-[(N-ACETYL-L-LEUCYL)AMINO]ETHYL}(HYDROXY)PHOSPHORYL]METHYL}-4-PHENYLBUTANOIC+ACID'>LA9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA9:(2S)-2-{[(R)-{(1R)-1-[(N-ACETYL-L-LEUCYL)AMINO]ETHYL}(HYDROXY)PHOSPHORYL]METHYL}-4-PHENYLBUTANOIC+ACID'>LA9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uef|4uef]], [[4uez|4uez]], [[4uf4|4uf4]], [[5aek|5aek]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uef|4uef]], [[4uez|4uez]], [[4uf4|4uf4]], [[5aek|5aek]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uee OCA], [http://pdbe.org/4uee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uee RCSB], [http://www.ebi.ac.uk/pdbsum/4uee PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uee OCA], [http://pdbe.org/4uee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uee RCSB], [http://www.ebi.ac.uk/pdbsum/4uee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uee ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>   
[[http://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>   
==See Also==
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 15: Line 19:
</StructureSection>
</StructureSection>
[[Category: Carboxypeptidase A]]
[[Category: Carboxypeptidase A]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Aviles, F X]]
[[Category: Aviles, F X]]
[[Category: Costenaro, L]]
[[Category: Costenaro, L]]

Revision as of 12:20, 21 May 2019

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OHCrystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH

Structural highlights

4uee is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Carboxypeptidase A, with EC number 3.4.17.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CBPA1_HUMAN] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.[1]

See Also

References

  1. ↑ Laethem RM, Blumenkopf TA, Cory M, Elwell L, Moxham CP, Ray PH, Walton LM, Smith GK. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. Arch Biochem Biophys. 1996 Aug 1;332(1):8-18. PMID:8806703 doi:http://dx.doi.org/S0003-9861(96)90310-0

4uee, resolution 2.27Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4uee&oldid=3044884"