2j0a: Difference between revisions

Revision as of 19:16, 5 November 2007

STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE

OverviewOverview

Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify, Notch receptors, altering their ligand-binding specificity to regulate, Notch signaling in development. We present the crystal structure of mouse, Manic Fringe bound to UDP and manganese. The structure reveals amino acid, residues involved in recognition of donor substrates and catalysis, and a, putative binding pocket for acceptor substrates. Mutations of several, invariant residues in this pocket impair Fringe activity in vivo.

About this StructureAbout this Structure

2J0A is a Single protein structure of sequence from Mus musculus with SO4 and K as ligands. Active as O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, with EC number 2.4.1.222 Structure known Active Site: AC1. Full crystallographic information is available from OCA.

ReferenceReference

Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258

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OCA

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	[[Category: transmembrane]]		[[Category: transmembrane]]

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