Cyclin-dependent kinase regulatory subunit: Difference between revisions

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CKS exists as hexamer of homodimers and can bind six kinase molecules.
CKS exists as hexamer of homodimers and can bind six kinase molecules.
== 3D Structures of cyclin-dependent kinase regulatory subunit ==
[[Cyclin-dependent kinase regulatory subunit 3D structures]]


</StructureSection>
</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|


*CKS
*CKS 1


**[[1dks]], [[1dkt]] – hCKS 1 - human<br />
**[[4lpa]], [[1qb3]] – yCKS 1 - yeast<br />
**[[4lpa]], [[1qb3]] – yCKS 1 - yeast<br />
**[[3qy2]] – yCKS 1 (mutant)<br />
**[[3qy2]] – yCKS 1 (mutant)<br />
**[[1puc]], [[1sce]] – fyCKS 1 – fission yeast<br />
**[[1puc]], [[1sce]] – fyCKS 1 – fission yeast<br />
**[[1dks]], [[1dkt]] – hCKS 1 - human<br />
**[[1cks]] – hCKS 2<br />
**[[1cks]] – hCKS 2<br />


*CKS complexes
*CKS 1 complexes


**[[4yc6]] – hCKS 1 + CDK1 <br />
**[[4yc6]] – hCKS 1 + CDK1 <br />
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**[[2ass]] – hCKS 1 + Skp1 + Skp2<br />
**[[2ass]] – hCKS 1 + Skp1 + Skp2<br />
**[[2ast]] – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide<br />
**[[2ast]] – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide<br />
**[[4y72]], [[4yc3]], [[5hq0]], [[5lqf]] – hCKS 2 + cyclin B1 + CDK1<br />
 
*CKS 2
 
**[[1cks]] – hCKS 2<br />
**[[4y72]], [[4yc3]], [[5hq0]], [[5lqf]] – hCKS 2 + CDK1 + cyclin B1<br />
**[[6gu2]] – hCKS 2 + CDK1 + cyclin B + flavopiridol<br />
**[[6gu7]] – hCKS 2 + CDK1 + inhibitor<br />
**[[6gu6]] – hCKS 2 + CDK1 + dinaciclib<br />
**[[6gu3]], [[6gu4]] – hCKS 2 + CDK1 + cyclin B + inhibitor<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:58, 21 May 2019

Function

Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation.[1]

Structural highlights

CKS exists as hexamer of homodimers and can bind six kinase molecules.

3D Structures of cyclin-dependent kinase regulatory subunit

Cyclin-dependent kinase regulatory subunit 3D structures


Human CKS-1 complex with phosphate (PDB code 1dks)

Drag the structure with the mouse to rotate

3D Structures of cyclin-dependent kinase regulatory subunit3D Structures of cyclin-dependent kinase regulatory subunit

Updated on 21-May-2019

ReferencesReferences

  1. ↑ Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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