4uu3: Difference between revisions
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==Ferulic acid decarboxylase from Enterobacter sp.== | ==Ferulic acid decarboxylase from Enterobacter sp.== | ||
<StructureSection load='4uu3' size='340' side='right' caption='[[4uu3]], [[Resolution|resolution]] 1.15Å' scene=''> | <StructureSection load='4uu3' size='340' side='right'caption='[[4uu3]], [[Resolution|resolution]] 1.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4uu3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4uu3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_sp. Enterobacter sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU3 FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uu2|4uu2]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uu2|4uu2]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu3 OCA], [http://pdbe.org/4uu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu3 OCA], [http://pdbe.org/4uu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uu3 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu3 ProSAT]</span></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Enterobacter sp]] | |||
[[Category: Large Structures]] | |||
[[Category: Faber, K]] | [[Category: Faber, K]] | ||
[[Category: Fauland, K]] | [[Category: Fauland, K]] | ||
Revision as of 11:44, 21 May 2019
Ferulic acid decarboxylase from Enterobacter sp.Ferulic acid decarboxylase from Enterobacter sp.
Structural highlights
Publication Abstract from PubMedWe report on a 'green' method for the utilization of carbon dioxide as C1 unit for the regioselective synthesis of (E)-cinnamic acids via regioselective enzymatic carboxylation of para-hydroxystyrenes. Phenolic acid decarboxylases from bacterial sources catalyzed the beta-carboxylation of para-hydroxystyrene derivatives with excellent regio- and (E/Z)-stereoselectivity by exclusively acting at the beta-carbon atom of the C=C side chain to furnish the corresponding (E)-cinnamic acid derivatives in up to 40% conversion at the expense of bicarbonate as carbon dioxide source. Studies on the substrate scope of this strategy are presented and a catalytic mechanism is proposed based on molecular modelling studies supported by mutagenesis of amino acid residues in the active site. Regioselective Enzymatic beta-Carboxylation of -Hydroxy- styrene Derivatives Catalyzed by Phenolic Acid Decarboxylases.,Wuensch C, Pavkov-Keller T, Steinkellner G, Gross J, Fuchs M, Hromic A, Lyskowski A, Fauland K, Gruber K, Glueck SM, Faber K Adv Synth Catal. 2015 May 26;357(8):1909-1918. Epub 2015 Apr 2. PMID:26190963[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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