6r7z: Difference between revisions

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<StructureSection load='6r7z' size='340' side='right'caption='[[6r7z]], [[Resolution|resolution]] 5.14&Aring;' scene=''>
<StructureSection load='6r7z' size='340' side='right'caption='[[6r7z]], [[Resolution|resolution]] 5.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6r7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[6r7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7Z FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7z OCA], [http://pdbe.org/6r7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7z RCSB], [http://www.ebi.ac.uk/pdbsum/6r7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7z ProSAT]</span></td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ANO10, TMEM16K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7z OCA], [http://pdbe.org/6r7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7z RCSB], [http://www.ebi.ac.uk/pdbsum/6r7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7z ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H]]

Revision as of 11:24, 21 May 2019

CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)

Structural highlights

6r7z is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:ANO10, TMEM16K (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[ANO10_HUMAN] Adult-onset autosomal recessive cerebellar ataxia. The disease is caused by mutations affecting the gene represented in this entry.

Function

[ANO10_HUMAN] Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.[1] [2]

References

  1. ↑ Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K. Expression and function of epithelial anoctamins. J Biol Chem. 2010 Mar 5;285(10):7838-45. doi: 10.1074/jbc.M109.065367. Epub 2010 , Jan 7. PMID:20056604 doi:http://dx.doi.org/10.1074/jbc.M109.065367
  2. ↑ Tian Y, Schreiber R, Kunzelmann K. Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci. 2012 Nov 1;125(Pt 21):4991-8. doi: 10.1242/jcs.109553. Epub 2012 Sep , 3. PMID:22946059 doi:http://dx.doi.org/10.1242/jcs.109553

6r7z, resolution 5.14Å

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