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==Spatial structure of purotoxin-1 in water== | ==Spatial structure of purotoxin-1 in water== | ||
<StructureSection load='2kgu' size='340' side='right' caption='[[2kgu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2kgu' size='340' side='right'caption='[[2kgu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kgu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kgu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Alomr Alomr]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGU FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">320151 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">320151 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2066572 ALOMR])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgu OCA], [http://pdbe.org/2kgu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kgu RCSB], [http://www.ebi.ac.uk/pdbsum/2kgu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgu ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgu OCA], [http://pdbe.org/2kgu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kgu RCSB], [http://www.ebi.ac.uk/pdbsum/2kgu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| Line 20: | Line 20: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Alomr]] | ||
[[Category: Large Structures]] | |||
[[Category: Arseniev, A]] | [[Category: Arseniev, A]] | ||
[[Category: Grishin, E]] | [[Category: Grishin, E]] | ||
Revision as of 10:44, 21 May 2019
Spatial structure of purotoxin-1 in waterSpatial structure of purotoxin-1 in water
Structural highlights
Publication Abstract from PubMedP2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa sp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain. Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain.,Grishin EV, Savchenko GA, Vassilevski AA, Korolkova YV, Boychuk YA, Viatchenko-Karpinski VY, Nadezhdin KD, Arseniev AS, Pluzhnikov KA, Kulyk VB, Voitenko NV, Krishtal OO Ann Neurol. 2010 May;67(5):680-3. PMID:20437566[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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