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==Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 5.5== | |||
<StructureSection load='6ilj' size='340' side='right'caption='[[6ilj]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ilj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e6 Echovirus e6] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ILJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr> | |||
[[Category: | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD55, CR, DAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ilj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ilj OCA], [http://pdbe.org/6ilj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ilj RCSB], [http://www.ebi.ac.uk/pdbsum/6ilj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ilj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Echovirus e6]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Gao, G F]] | |||
[[Category: Liu, S]] | |||
[[Category: Peng, R]] | |||
[[Category: Zhao, X]] | |||
[[Category: Cd55]] | |||
[[Category: Cryo-em]] | |||
[[Category: Echovirus 6]] | |||
[[Category: Virus]] | |||
[[Category: Virus-receptor complex]] | |||
Revision as of 10:27, 21 May 2019
Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 5.5Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 5.5
Structural highlights
Function[DAF_HUMAN] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.[1] References |
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