Crystallin: Difference between revisions

Revision as of 12:39, 20 May 2019

Function

Crystallin is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. α-, β-, γ-, δ-crystallin are named according to the order they are eluted by gel filtration. δ-crystallin is found in avian and reptilian lenses.^[1]

Disease

Several human cataracts have been linked to mutations in γ-D-crystallin^[2].

3D Structures of Crystallin

Crystallin 3D structures

3D Structures of Crystallin3D Structures of Crystallin

Updated on 20-May-2019

2g98 - hγ-D-crystalline – human
1h4a - hγ-D-crystalline (mutant)
1elp - γ-D-crystalline – bovine
1auw - δ-2-crystalline (mutant) - duck

ReferencesReferences

↑ Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J. High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract. J Mol Biol. 2003 May 16;328(5):1137-47. PMID:12729747
↑ Pande A, Pande J, Asherie N, Lomakin A, Ogun O, King J, Benedek GB. Crystal cataracts: human genetic cataract caused by protein crystallization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6116-20. PMID:11371638 doi:http://dx.doi.org/10.1073/pnas.101124798

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

[1] Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J. High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract. J Mol Biol. 2003 May 16;328(5):1137-47. PMID:12729747

[2] Pande A, Pande J, Asherie N, Lomakin A, Ogun O, King J, Benedek GB. Crystal cataracts: human genetic cataract caused by protein crystallization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6116-20. PMID:11371638 doi:http://dx.doi.org/10.1073/pnas.101124798

[1]

[2]

@@ Line 1: / Line 1: @@
-<StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystalline,  [[2g98]]'>
+<StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystallin,  [[2g98]]'>
 == Function ==
-'''Crystalline''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it.  α-, β-, γ-, δ-crystalline are named according to the order they are eluted by gel filtration. δ-crystalline is found in avian and reptilian lenses.<ref>PMID:12729747</ref>
+'''Crystallin''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it.  α-, β-, γ-, δ-crystallin are named according to the order they are eluted by gel filtration. δ-crystallin is found in avian and reptilian lenses.<ref>PMID:12729747</ref>
 == Disease ==
-Several human cataracts have been linked to mutations in γ-D-crystalline<ref>PMID:11371638</ref>.
+Several human cataracts have been linked to mutations in γ-D-crystallin<ref>PMID:11371638</ref>.
+== 3D Structures of Crystallin ==
+[[Crystallin 3D structures]]
 </StructureSection>
-== 3D Structures of Crystalline ==
+== 3D Structures of Crystallin ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 [[2g98]] - hγ-D-crystalline – human<br />